Reynolds CH - Search Results

1

Modeling the protonation states of the catalytic aspartates in beta-secretase.

Rajamani R, Reynolds CH. Rajamani R, et al. Among authors: reynolds ch. J Med Chem. 2004 Oct 7;47(21):5159-66. doi: 10.1021/jm049817j. J Med Chem. 2004. PMID: 15456259

2

Modeling the binding affinities of beta-secretase inhibitors: application to subsite specificity.

Rajamani R, Reynolds CH. Rajamani R, et al. Among authors: reynolds ch. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4843-6. doi: 10.1016/j.bmcl.2004.07.044. Bioorg Med Chem Lett. 2004. PMID: 15341936

3

A two-state homology model of the hERG K+ channel: application to ligand binding.

Rajamani R, Tounge BA, Li J, Reynolds CH. Rajamani R, et al. Among authors: reynolds ch. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1737-41. doi: 10.1016/j.bmcl.2005.01.008. Bioorg Med Chem Lett. 2005. PMID: 15745831

4

Linear interaction energy models for beta-secretase (BACE) inhibitors: Role of van der Waals, electrostatic, and continuum-solvation terms.

Tounge BA, Rajamani R, Baxter EW, Reitz AB, Reynolds CH. Tounge BA, et al. Among authors: reynolds ch. J Mol Graph Model. 2006 May;24(6):475-84. doi: 10.1016/j.jmgm.2005.10.002. Epub 2005 Nov 15. J Mol Graph Model. 2006. PMID: 16293430

5

Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method.

Tounge BA, Reynolds CH. Tounge BA, et al. Among authors: reynolds ch. J Med Chem. 2003 May 22;46(11):2074-82. doi: 10.1021/jm020513b. J Med Chem. 2003. PMID: 12747779

6

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.

Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: reynolds ch. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503

7

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.

Huang Y, Strobel ED, Ho CY, Reynolds CH, Conway KA, Piesvaux JA, Brenneman DE, Yohrling GJ, Moore Arnold H, Rosenthal D, Alexander RS, Tounge BA, Mercken M, Vandermeeren M, Parker MH, Reitz AB, Baxter EW. Huang Y, et al. Among authors: reynolds ch. Bioorg Med Chem Lett. 2010 May 15;20(10):3158-60. doi: 10.1016/j.bmcl.2010.03.097. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399652

8

Ligand binding efficiency: trends, physical basis, and implications.

Reynolds CH, Tounge BA, Bembenek SD. Reynolds CH, et al. J Med Chem. 2008 Apr 24;51(8):2432-8. doi: 10.1021/jm701255b. Epub 2008 Apr 2. J Med Chem. 2008. PMID: 18380424

9

Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.

Lee J, Reynolds C, Jetter MC, Youngman MA, Hlasta DJ, Dax SL, Stone DJ, Zhang SP, Codd EE. Lee J, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1879-82. doi: 10.1016/s0960-894x(03)00309-3. Bioorg Med Chem Lett. 2003. PMID: 12749889

10

The role of molecular size in ligand efficiency.

Reynolds CH, Bembenek SD, Tounge BA. Reynolds CH, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4258-61. doi: 10.1016/j.bmcl.2007.05.038. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17532632

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