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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. Yamaguchi O, et al. J Clin Invest. 2004 Oct;114(7):937-43. doi: 10.1172/JCI20317. J Clin Invest. 2004. PMID: 15467832 Free PMC article.
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Hori M. Higuchi Y, et al. Among authors: yamaguchi o. J Biol Chem. 2003 Jun 6;278(23):20770-7. doi: 10.1074/jbc.M213203200. Epub 2003 Apr 2. J Biol Chem. 2003. PMID: 12672819 Free article.
593 results