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A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts.
Birkett A, Lyons K, Schmidt A, Boyd D, Oliveira GA, Siddique A, Nussenzweig R, Calvo-Calle JM, Nardin E. Birkett A, et al. Infect Immun. 2002 Dec;70(12):6860-70. doi: 10.1128/IAI.70.12.6860-6870.2002. Infect Immun. 2002. PMID: 12438363 Free PMC article.
Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial.
Oliveira GA, Wetzel K, Calvo-Calle JM, Nussenzweig R, Schmidt A, Birkett A, Dubovsky F, Tierney E, Gleiter CH, Boehmer G, Luty AJ, Ramharter M, Thornton GB, Kremsner PG, Nardin EH. Oliveira GA, et al. Among authors: birkett a. Infect Immun. 2005 Jun;73(6):3587-97. doi: 10.1128/IAI.73.6.3587-3597.2005. Infect Immun. 2005. PMID: 15908388 Free PMC article. Clinical Trial.
Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA.
Ferraro B, Talbott KT, Balakrishnan A, Cisper N, Morrow MP, Hutnick NA, Myles DJ, Shedlock DJ, Obeng-Adjei N, Yan J, Kayatani AK, Richie N, Cabrera W, Shiver R, Khan AS, Brown AS, Yang M, Wille-Reece U, Birkett AJ, Sardesai NY, Weiner DB. Ferraro B, et al. Among authors: birkett aj. Infect Immun. 2013 Oct;81(10):3709-20. doi: 10.1128/IAI.00180-13. Epub 2013 Jul 29. Infect Immun. 2013. PMID: 23897618 Free PMC article.
A "universal" human influenza A vaccine.
Fiers W, De Filette M, Birkett A, Neirynck S, Min Jou W. Fiers W, et al. Virus Res. 2004 Jul;103(1-2):173-6. doi: 10.1016/j.virusres.2004.02.030. Virus Res. 2004. PMID: 15163506 Review.
An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria.
Reuling IJ, Mendes AM, de Jong GM, Fabra-García A, Nunes-Cabaço H, van Gemert GJ, Graumans W, Coffeng LE, de Vlas SJ, Yang ASP, Lee C, Wu Y, Birkett AJ, Ockenhouse CF, Koelewijn R, van Hellemond JJ, van Genderen PJJ, Sauerwein RW, Prudêncio M. Reuling IJ, et al. Among authors: birkett aj. Sci Transl Med. 2020 May 20;12(544):eaay2578. doi: 10.1126/scitranslmed.aay2578. Sci Transl Med. 2020. PMID: 32434846 Clinical Trial.
56 results