Nienaber VL - Search Results

1

A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

Atwell S, Adams JM, Badger J, Buchanan MD, Feil IK, Froning KJ, Gao X, Hendle J, Keegan K, Leon BC, Müller-Dieckmann HJ, Nienaber VL, Noland BW, Post K, Rajashankar KR, Ramos A, Russell M, Burley SK, Buchanan SG. Atwell S, et al. Among authors: nienaber vl. J Biol Chem. 2004 Dec 31;279(53):55827-32. doi: 10.1074/jbc.M409792200. Epub 2004 Oct 26. J Biol Chem. 2004. PMID: 15507431 Free article.

2

X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.

Mezo AR, Sridhar V, Badger J, Sakorafas P, Nienaber V. Mezo AR, et al. J Biol Chem. 2010 Sep 3;285(36):27694-701. doi: 10.1074/jbc.M110.120667. Epub 2010 Jun 30. J Biol Chem. 2010. PMID: 20592032 Free PMC article.

3

Structure determination of LpxD from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.

Badger J, Chie-Leon B, Logan C, Sridhar V, Sankaran B, Zwart PH, Nienaber V. Badger J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):6-9. doi: 10.1107/S1744309112048890. Epub 2012 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 23295477 Free PMC article.

4

The structure of LpxD from Pseudomonas aeruginosa at 1.3 Å resolution.

Badger J, Chie-Leon B, Logan C, Sridhar V, Sankaran B, Zwart PH, Nienaber V. Badger J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):749-52. doi: 10.1107/S1744309111018811. Epub 2011 Jun 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21795786 Free PMC article.

5

Structure determination of LpxA from the lipopolysaccharide-synthesis pathway of Acinetobacter baumannii.

Badger J, Chie-Leon B, Logan C, Sridhar V, Sankaran B, Zwart PH, Nienaber V. Badger J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1477-81. doi: 10.1107/S174430911204571X. Epub 2012 Nov 28. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23192027 Free PMC article.

6

Fragment-based screening for inhibitors of PDE4A using enthalpy arrays and X-ray crystallography.

Recht MI, Sridhar V, Badger J, Hernandez L, Chie-Leon B, Nienaber V, Torres FE. Recht MI, et al. J Biomol Screen. 2012 Apr;17(4):469-80. doi: 10.1177/1087057111430987. Epub 2012 Jan 5. J Biomol Screen. 2012. PMID: 22223051 Free PMC article.

7

Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.

Parker AR, Petluru PN, Nienaber VL, Zhao M, Ayala PY, Badger J, Chie-Leon B, Sridhar V, Logan C, Kochat H, Hausheer FH. Parker AR, et al. Among authors: nienaber vl. Onco Targets Ther. 2015 Feb 4;8:375-83. doi: 10.2147/OTT.S73690. eCollection 2015. Onco Targets Ther. 2015. PMID: 25678804 Free PMC article.

8

Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787.

Parker AR, Petluru PN, Nienaber VL, Badger J, Leverett BD, Jair K, Sridhar V, Logan C, Ayala PY, Kochat H, Hausheer FH. Parker AR, et al. Among authors: nienaber vl. Molecules. 2015 Mar 18;20(3):4928-50. doi: 10.3390/molecules20034928. Molecules. 2015. PMID: 25793542 Free PMC article.

9

Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite.

Nienaber V, Wang J, Davidson D, Henkin J. Nienaber V, et al. J Biol Chem. 2000 Mar 10;275(10):7239-48. doi: 10.1074/jbc.275.10.7239. J Biol Chem. 2000. PMID: 10702294 Free article.

10

Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.

Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE. Recht MI, et al. J Biomol Screen. 2014 Apr;19(4):497-507. doi: 10.1177/1087057113516493. Epub 2013 Dec 27. J Biomol Screen. 2014. PMID: 24375910 Free PMC article.

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