Martins LM - Search Results

1

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J. Martins LM, et al. Mol Cell Biol. 2004 Nov;24(22):9848-62. doi: 10.1128/MCB.24.22.9848-9862.2004. Mol Cell Biol. 2004. PMID: 15509788 Free PMC article.

2

Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis.

Rytömaa M, Martins LM, Downward J. Rytömaa M, et al. Among authors: martins lm. Curr Biol. 1999 Sep 23;9(18):1043-6. doi: 10.1016/s0960-9822(99)80454-0. Curr Biol. 1999. PMID: 10508619 Free article.

3

The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.

Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR. Zhao J, et al. Among authors: martins lm. J Cell Sci. 2000 Dec;113 Pt 23:4363-71. doi: 10.1242/jcs.113.23.4363. J Cell Sci. 2000. PMID: 11069780

4

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.

Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J. Martins LM, et al. J Biol Chem. 2002 Jan 4;277(1):439-44. doi: 10.1074/jbc.M109784200. Epub 2001 Oct 15. J Biol Chem. 2002. PMID: 11602612 Free article.

5

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.

Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Martins LM, et al. J Biol Chem. 2003 Dec 5;278(49):49417-27. doi: 10.1074/jbc.M308659200. Epub 2003 Sep 25. J Biol Chem. 2003. PMID: 14512424 Free article.

6

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.

Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG. Baksh S, et al. Among authors: martins lm. Mol Cell. 2005 Jun 10;18(6):637-50. doi: 10.1016/j.molcel.2005.05.010. Mol Cell. 2005. PMID: 15949439 Free article.

7

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R. Strauss KM, et al. Among authors: martins lm. Hum Mol Genet. 2005 Aug 1;14(15):2099-111. doi: 10.1093/hmg/ddi215. Epub 2005 Jun 16. Hum Mol Genet. 2005. PMID: 15961413

8

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. Plun-Favreau H, et al. Among authors: martins lm. Nat Cell Biol. 2007 Nov;9(11):1243-52. doi: 10.1038/ncb1644. Epub 2007 Sep 30. Nat Cell Biol. 2007. PMID: 17906618

9

Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.

Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R. Kawamoto Y, et al. Among authors: martins lm. J Neuropathol Exp Neurol. 2008 Oct;67(10):984-93. doi: 10.1097/NEN.0b013e31818809f4. J Neuropathol Exp Neurol. 2008. PMID: 18800009

10

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.

Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM. Moisoi N, et al. Among authors: martins lm. Cell Death Differ. 2009 Mar;16(3):449-64. doi: 10.1038/cdd.2008.166. Epub 2008 Nov 21. Cell Death Differ. 2009. PMID: 19023330

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