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The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.
Stiborová M, Sejbal J, Borek-Dohalská L, Aimová D, Poljaková J, Forsterová K, Rupertová M, Wiesner J, Hudecek J, Wiessler M, Frei E. Stiborová M, et al. Among authors: poljakova j. Cancer Res. 2004 Nov 15;64(22):8374-80. doi: 10.1158/0008-5472.CAN-04-2202. Cancer Res. 2004. PMID: 15548707
Oxidation of an antitumor drug ellipticine by peroxidases.
Poljaková J, Forsterová K, Sulc M, Frei E, Stiborová M. Poljaková J, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):449-53. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601808
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