Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.
Shirota Y, Luo H, Qin W, Kaneko S, Yamashita T, Kobayashi K, Murakami S.
Shirota Y, et al. Among authors: kaneko s.
J Biol Chem. 2002 Mar 29;277(13):11149-55. doi: 10.1074/jbc.M111392200. Epub 2002 Jan 18.
J Biol Chem. 2002.
PMID: 11801599
Free article.
Here we report that purified bacterial recombinant NS5A and NS5B directly interact with each other in vitro, detected by glutathione S-transferase (GST) pull-down assay. Furthermore, complex formation of these proteins transiently coexpressed in mammalian cells was detecte …
Here we report that purified bacterial recombinant NS5A and NS5B directly interact with each other in vitro, detected by glutathione S …