Zhou P - Search Results

1

N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.

Cole DC, Ellingboe JW, Lennox WJ, Mazandarani H, Smith DL, Stock JR, Zhang G, Zhou P, Schechter LE. Cole DC, et al. Among authors: zhou p. Bioorg Med Chem Lett. 2005 Jan 17;15(2):379-83. doi: 10.1016/j.bmcl.2004.10.064. Bioorg Med Chem Lett. 2005. PMID: 15603958

2

Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.

Mewshaw RE, Meagher KL, Zhou P, Zhou D, Shi X, Scerni R, Smith D, Schechter LE, Andree TH. Mewshaw RE, et al. Among authors: zhou d, zhou p. Bioorg Med Chem Lett. 2002 Feb 11;12(3):307-10. doi: 10.1016/s0960-894x(01)00746-6. Bioorg Med Chem Lett. 2002. PMID: 11814784

3

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH. Mewshaw RE, et al. Among authors: zhou d, zhou p. J Med Chem. 2004 Jul 15;47(15):3823-42. doi: 10.1021/jm0304010. J Med Chem. 2004. PMID: 15239661

4

Studies towards the next generation of antidepressants. Part 4: derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor.

Evrard DA, Zhou P, Yi SY, Zhou D, Smith DL, Sullivan KM, Hornby GA, Schechter LE, Andree TH, Mewshaw RE. Evrard DA, et al. Among authors: zhou d, zhou p. Bioorg Med Chem Lett. 2005 Feb 15;15(4):911-4. doi: 10.1016/j.bmcl.2004.12.064. Bioorg Med Chem Lett. 2005. PMID: 15686885

5

4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands.

Zhou P, Yan Y, Bernotas R, Harrison BL, Huryn D, Robichaud AJ, Zhang GM, Smith DL, Schechter LE. Zhou P, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1393-6. doi: 10.1016/j.bmcl.2005.01.005. Bioorg Med Chem Lett. 2005. PMID: 15713394

6

Acylguanidines as small-molecule beta-secretase inhibitors.

Cole DC, Manas ES, Stock JR, Condon JS, Jennings LD, Aulabaugh A, Chopra R, Cowling R, Ellingboe JW, Fan KY, Harrison BL, Hu Y, Jacobsen S, Jin G, Lin L, Lovering FE, Malamas MS, Stahl ML, Strand J, Sukhdeo MN, Svenson K, Turner MJ, Wagner E, Wu J, Zhou P, Bard J. Cole DC, et al. Among authors: zhou p. J Med Chem. 2006 Oct 19;49(21):6158-61. doi: 10.1021/jm0607451. J Med Chem. 2006. PMID: 17034121

7

Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.

Zhou D, Zhou P, Evrard DA, Meagher K, Webb M, Harrison BL, Huryn DM, Golembieski J, Hornby GA, Schechter LE, Smith DL, Andree TH, Mewshaw RE. Zhou D, et al. Among authors: zhou p. Bioorg Med Chem. 2008 Jul 15;16(14):6707-23. doi: 10.1016/j.bmc.2008.05.075. Epub 2008 Jun 5. Bioorg Med Chem. 2008. PMID: 18571421

8

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

Nowak P, Cole DC, Aulabaugh A, Bard J, Chopra R, Cowling R, Fan KY, Hu B, Jacobsen S, Jani M, Jin G, Lo MC, Malamas MS, Manas ES, Narasimhan R, Reinhart P, Robichaud AJ, Stock JR, Subrath J, Svenson K, Turner J, Wagner E, Zhou P, Ellingboe JW. Nowak P, et al. Among authors: zhou p. Bioorg Med Chem Lett. 2010 Jan 15;20(2):632-5. doi: 10.1016/j.bmcl.2009.11.052. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 19959359

9

Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.

Hu B, Fan KY, Bridges K, Chopra R, Lovering F, Cole D, Zhou P, Ellingboe J, Jin G, Cowling R, Bard J. Hu B, et al. Among authors: zhou p. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3457-60. doi: 10.1016/j.bmcl.2004.04.068. Bioorg Med Chem Lett. 2004. PMID: 15177452

10

Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.

Meagher KL, Mewshaw RE, Evrard DA, Zhou P, Smith DL, Scerni R, Spangler T, Abulhawa S, Shi X, Schechter LE, Andree TH. Meagher KL, et al. Among authors: zhou p. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1885-8. doi: 10.1016/s0960-894x(01)00334-1. Bioorg Med Chem Lett. 2001. PMID: 11459653

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