Mould AP - Search Results

1

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ. Humphries JD, et al. Among authors: mould ap. J Biol Chem. 2005 Mar 18;280(11):10234-43. doi: 10.1074/jbc.M411102200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632175 Free PMC article.

2

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.

Mould AP, Askari JA, Barton S, Kline AD, McEwan PA, Craig SE, Humphries MJ. Mould AP, et al. J Biol Chem. 2002 May 31;277(22):19800-5. doi: 10.1074/jbc.M201571200. Epub 2002 Mar 13. J Biol Chem. 2002. PMID: 11893752 Free article.

3

E-cadherin is a ligand for integrin alpha2beta1.

Whittard JD, Craig SE, Mould AP, Koch A, Pertz O, Engel J, Humphries MJ. Whittard JD, et al. Among authors: mould ap. Matrix Biol. 2002 Oct;21(6):525-32. doi: 10.1016/s0945-053x(02)00037-9. Matrix Biol. 2002. PMID: 12392763

4

Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement.

Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, Humphries MJ. Mould AP, et al. J Biol Chem. 2003 May 9;278(19):17028-35. doi: 10.1074/jbc.M213139200. Epub 2003 Mar 3. J Biol Chem. 2003. PMID: 12615914 Free article.

5

Mapping functional residues onto integrin crystal structures.

Humphries MJ, Symonds EJ, Mould AP. Humphries MJ, et al. Among authors: mould ap. Curr Opin Struct Biol. 2003 Apr;13(2):236-43. doi: 10.1016/s0959-440x(03)00035-6. Curr Opin Struct Biol. 2003. PMID: 12727518 Review.

6

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble.

Humphries MJ, McEwan PA, Barton SJ, Buckley PA, Bella J, Mould AP. Humphries MJ, et al. Among authors: mould ap. Trends Biochem Sci. 2003 Jun;28(6):313-20. doi: 10.1016/s0968-0004(03)00112-9. Trends Biochem Sci. 2003. PMID: 12826403 Review.

7

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

Mould AP, Symonds EJ, Buckley PA, Grossmann JG, McEwan PA, Barton SJ, Askari JA, Craig SE, Bella J, Humphries MJ. Mould AP, et al. J Biol Chem. 2003 Oct 10;278(41):39993-9. doi: 10.1074/jbc.M304627200. Epub 2003 Jul 19. J Biol Chem. 2003. PMID: 12871973 Free article.

8

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

Mould AP, Barton SJ, Askari JA, Craig SE, Humphries MJ. Mould AP, et al. J Biol Chem. 2003 Dec 19;278(51):51622-9. doi: 10.1074/jbc.M306655200. Epub 2003 Oct 7. J Biol Chem. 2003. PMID: 14532288 Free article.

9

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

Mould AP, Humphries MJ. Mould AP, et al. Curr Opin Cell Biol. 2004 Oct;16(5):544-51. doi: 10.1016/j.ceb.2004.07.003. Curr Opin Cell Biol. 2004. PMID: 15363805 Review.

10

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, Macdonald PR, Kammerer RA, Buckley PA, Humphries MJ. Mould AP, et al. J Biol Chem. 2005 Feb 11;280(6):4238-46. doi: 10.1074/jbc.M412240200. Epub 2004 Nov 22. J Biol Chem. 2005. PMID: 15557320 Free PMC article.

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