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The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.
Escrieut C, Gigoux V, Archer E, Verrier S, Maigret B, Behrendt R, Moroder L, Bignon E, Silvente-Poirot S, Pradayrol L, Fourmy D. Escrieut C, et al. Among authors: fourmy d. J Biol Chem. 2002 Mar 1;277(9):7546-55. doi: 10.1074/jbc.M108563200. Epub 2001 Nov 27. J Biol Chem. 2002. PMID: 11724786 Free article.
Identification of putative amino acids of the CCK1R binding site was achieved by dynamics-based docking of the ligand CCK in a refined three-dimensional model of the CCK1R using, as constraints, previous results that identified contact points between residues of CCK and CCK1R (Ke …
Identification of putative amino acids of the CCK1R binding site was achieved by dynamics-based docking of the ligand CCK in a refined three …
The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.
Arnould M, Tassa A, Ferrand A, Archer E, Estève JP, Pénalba V, Portolan G, Escherich A, Moroder L, Fourmy D, Seva C, Dufresne M. Arnould M, et al. Among authors: fourmy d. FEBS Lett. 2004 Jun 18;568(1-3):89-93. doi: 10.1016/j.febslet.2004.05.012. FEBS Lett. 2004. PMID: 15196926 Free article.
Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells.
Leung-Theung-Long S, Roulet E, Clerc P, Escrieut C, Marchal-Victorion S, Ritz-Laser B, Philippe J, Pradayrol L, Seva C, Fourmy D, Dufresne M. Leung-Theung-Long S, et al. Among authors: fourmy d. J Biol Chem. 2005 Mar 4;280(9):7976-84. doi: 10.1074/jbc.M407485200. Epub 2004 Dec 14. J Biol Chem. 2005. PMID: 15611055 Free article.
174 results