Lu T - Search Results

1

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.

Parks DJ, Lafrance LV, Calvo RR, Milkiewicz KL, Gupta V, Lattanze J, Ramachandren K, Carver TE, Petrella EC, Cummings MD, Maguire D, Grasberger BL, Lu T. Parks DJ, et al. Among authors: lu t. Bioorg Med Chem Lett. 2005 Feb 1;15(3):765-70. doi: 10.1016/j.bmcl.2004.11.009. Bioorg Med Chem Lett. 2005. PMID: 15664854

2

Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.

Bone R, Lu T, Illig CR, Soll RM, Spurlino JC. Bone R, et al. Among authors: lu t. J Med Chem. 1998 Jun 4;41(12):2068-75. doi: 10.1021/jm970796l. J Med Chem. 1998. PMID: 9622548

3

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.

Lu T, Tomczuk B, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Soll RM. Lu T, et al. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1595-600. doi: 10.1016/s0960-894x(98)00290-x. Bioorg Med Chem Lett. 1998. PMID: 9873397

4

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.

Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR. Soll RM, et al. Among authors: lu t. Bioorg Med Chem Lett. 2000 Jan 3;10(1):1-4. doi: 10.1016/s0960-894x(99)00632-0. Bioorg Med Chem Lett. 2000. PMID: 10636229

5

Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.

Lu T, Soll RM, Illig CR, Bone R, Murphy L, Spurlino J, Salemme FR, Tomczuk BE. Lu T, et al. Bioorg Med Chem Lett. 2000 Jan 3;10(1):79-82. doi: 10.1016/s0960-894x(99)00617-4. Bioorg Med Chem Lett. 2000. PMID: 10636249

6

Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.

Lu T, Tomczuk B, Bone R, Murphy L, Salemme FR, Soll RM. Lu T, et al. Bioorg Med Chem Lett. 2000 Jan 3;10(1):83-5. doi: 10.1016/s0960-894x(99)00616-2. Bioorg Med Chem Lett. 2000. PMID: 10636250

7

Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.

Tomczuk B, Lu T, Soll RM, Fedde C, Wang A, Murphy L, Crysler C, Dasgupta M, Eisennagel S, Spurlino J, Bone R. Tomczuk B, et al. Among authors: lu t. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1495-8. doi: 10.1016/s0960-894x(03)00125-2. Bioorg Med Chem Lett. 2003. PMID: 12668020

8

Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.

Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Lu T, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. doi: 10.1016/j.bmcl.2004.05.002. Bioorg Med Chem Lett. 2004. PMID: 15203151

9

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF. Grasberger BL, et al. Among authors: lu t. J Med Chem. 2005 Feb 24;48(4):909-12. doi: 10.1021/jm049137g. J Med Chem. 2005. PMID: 15715460

10

Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core.

Marugán JJ, Manthey C, Anaclerio B, Lafrance L, Lu T, Markotan T, Leonard KA, Crysler C, Eisennagel S, Dasgupta M, Tomczuk B. Marugán JJ, et al. Among authors: lu t. J Med Chem. 2005 Feb 24;48(4):926-34. doi: 10.1021/jm049725u. J Med Chem. 2005. PMID: 15715463

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