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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Wade JD, Barnham KJ. Tickler AK, et al. Among authors: barnham kj. J Biol Chem. 2005 Apr 8;280(14):13355-63. doi: 10.1074/jbc.M414178200. Epub 2005 Jan 24. J Biol Chem. 2005. PMID: 15668252 Free article.
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ. Curtain CC, et al. Among authors: barnham kj. J Biol Chem. 2001 Jun 8;276(23):20466-73. doi: 10.1074/jbc.M100175200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274207 Free article.
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Cherny RA, et al. Among authors: barnham kj. Neuron. 2001 Jun;30(3):665-76. doi: 10.1016/s0896-6273(01)00317-8. Neuron. 2001. PMID: 11430801 Free article.
Structure and activity of D-Pro14 melittin.
Hewish DR, Barnham KJ, Werkmeister JA, Kirkpatrick A, Bartone N, Liu ST, Norton RS, Curtain C, Rivetta DE. Hewish DR, et al. Among authors: barnham kj. J Protein Chem. 2002 May;21(4):243-53. doi: 10.1023/a:1019741202601. J Protein Chem. 2002. PMID: 12168695
206 results