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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Wade JD, Barnham KJ. Tickler AK, et al. Among authors: wade jd. J Biol Chem. 2005 Apr 8;280(14):13355-63. doi: 10.1074/jbc.M414178200. Epub 2005 Jan 24. J Biol Chem. 2005. PMID: 15668252 Free article.
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: wade jd. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
The role of Abeta peptides in Alzheimer's disease.
Tickler AK, Wade JD, Separovic F. Tickler AK, et al. Among authors: wade jd. Protein Pept Lett. 2005 Aug;12(6):513-9. doi: 10.2174/0929866054395905. Protein Pept Lett. 2005. PMID: 16101387 Review.
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Puglielli L, et al. Among authors: wade jd. J Clin Invest. 2005 Sep;115(9):2556-63. doi: 10.1172/JCI23610. Epub 2005 Aug 25. J Clin Invest. 2005. PMID: 16127459 Free PMC article.
286 results