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The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Caraglia M, Marra M, Viscomi C, D'Alessandro AM, Budillon A, Meo G, Arra C, Barbieri A, Rapp UR, Baldi A, Tassone P, Venuta S, Abbruzzese A, Tagliaferri P. Caraglia M, et al. Among authors: viscomi c. Int J Cancer. 2007 Nov 15;121(10):2317-30. doi: 10.1002/ijc.22964. Int J Cancer. 2007. PMID: 17657738
In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.
Neri P, Tagliaferri P, Di Martino MT, Calimeri T, Amodio N, Bulotta A, Ventura M, Eramo PO, Viscomi C, Arbitrio M, Rossi M, Caraglia M, Munshi NC, Anderson KC, Tassone P. Neri P, et al. Among authors: viscomi c. Br J Haematol. 2008 Nov;143(4):520-31. doi: 10.1111/j.1365-2141.2008.07387.x. Br J Haematol. 2008. PMID: 18986388 Free article.
C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
Lamberti A, Longo O, Marra M, Tagliaferri P, Bismuto E, Fiengo A, Viscomi C, Budillon A, Rapp UR, Wang E, Venuta S, Abbruzzese A, Arcari P, Caraglia M. Lamberti A, et al. Among authors: viscomi c. Cell Death Differ. 2007 May;14(5):952-62. doi: 10.1038/sj.cdd.4402102. Epub 2007 Mar 2. Cell Death Differ. 2007. PMID: 17332776
The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.
Caraglia M, D'Alessandro AM, Marra M, Giuberti G, Vitale G, Viscomi C, Colao A, Prete SD, Tagliaferri P, Tassone P, Budillon A, Venuta S, Abbruzzese A. Caraglia M, et al. Among authors: viscomi c. Oncogene. 2004 Sep 9;23(41):6900-13. doi: 10.1038/sj.onc.1207814. Oncogene. 2004. PMID: 15286715
Elexacaftor/tezacaftor/ivacaftor efficacy in intestinal organoids with rare CFTR variants in comparison to CFTR-F508del and CFTR-wild type controls.
Kroes S, Bierlaagh MC, Lefferts JW, Boni A, Muilwijk D, Viscomi C, Keijzer-Nieuwenhuijze NDA, Cristiani L, Niemöller PJ, Verburg TF, Cutrera R, Fiocchi AG, Lucidi V, van der Ent CK, Beekman JM, Alghisi F, Ciciriello F. Kroes S, et al. Among authors: viscomi c. J Cyst Fibros. 2024 Nov 9:S1569-1993(24)01787-9. doi: 10.1016/j.jcf.2024.09.019. Online ahead of print. J Cyst Fibros. 2024. PMID: 39523185
Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment.
Brañas Casas R, Zuppardo A, Risato G, Dinarello A, Celeghin R, Fontana C, Grelloni E, Gilea AI, Viscomi C, Rasola A, Dalla Valle L, Lodi T, Baruffini E, Facchinello N, Argenton F, Tiso N. Brañas Casas R, et al. Among authors: viscomi c. Cell Death Dis. 2024 Apr 20;15(4):281. doi: 10.1038/s41419-024-06622-9. Cell Death Dis. 2024. PMID: 38643274 Free PMC article.
Mitochondrial complex I activity in microglia sustains neuroinflammation.
Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, Reisz JA, Prag HA, Garcia-Segura ME, Wu V, Xiang Y, Barlas B, Casey AM, van den Bosch AMR, Nicaise AM, Roth L, Bates GR, Huang H, Prasad P, Vincent AE, Frezza C, Viscomi C, Balmus G, Takats Z, Marioni JC, D'Alessandro A, Murphy MP, Mohorianu I, Pluchino S. Peruzzotti-Jametti L, et al. Among authors: viscomi c. Nature. 2024 Apr;628(8006):195-203. doi: 10.1038/s41586-024-07167-9. Epub 2024 Mar 13. Nature. 2024. PMID: 38480879 Free PMC article.
153 results