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CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.
Baron BM, Cregge RJ, Farr RA, Friedrich D, Gross RS, Harrison BL, Janowick DA, Matthews D, McCloskey TC, Meikrantz S, Nyce PL, Vaz R, Metz WA. Baron BM, et al. Among authors: metz wa. J Med Chem. 2005 Feb 24;48(4):995-1018. doi: 10.1021/jm0491849. J Med Chem. 2005. PMID: 15715469
Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C. Cregge RJ, et al. Among authors: metz wa. J Med Chem. 1998 Jul 2;41(14):2461-80. doi: 10.1021/jm970812e. J Med Chem. 1998. PMID: 9651152
Design of potent IGF1-R inhibitors related to bis-azaindoles.
Nemecek C, Metz WA, Wentzler S, Ding FX, Venot C, Souaille C, Dagallier A, Maignan S, Guilloteau JP, Bernard F, Henry A, Grapinet S, Lesuisse D. Nemecek C, et al. Among authors: metz wa. Chem Biol Drug Des. 2010 Aug;76(2):100-6. doi: 10.1111/j.1747-0285.2010.00991.x. Epub 2010 Jun 9. Chem Biol Drug Des. 2010. PMID: 20545947
12 results