Roodveldt C - Search Results

1

Directed evolution of proteins for heterologous expression and stability.

Roodveldt C, Aharoni A, Tawfik DS. Roodveldt C, et al. Curr Opin Struct Biol. 2005 Feb;15(1):50-6. doi: 10.1016/j.sbi.2005.01.001. Curr Opin Struct Biol. 2005. PMID: 15718133 Review.

2

Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state.

Roodveldt C, Tawfik DS. Roodveldt C, et al. Protein Eng Des Sel. 2005 Jan;18(1):51-8. doi: 10.1093/protein/gzi005. Protein Eng Des Sel. 2005. PMID: 15790580

3

Enzyme promiscuity: evolutionary and mechanistic aspects.

Khersonsky O, Roodveldt C, Tawfik DS. Khersonsky O, et al. Among authors: roodveldt c. Curr Opin Chem Biol. 2006 Oct;10(5):498-508. doi: 10.1016/j.cbpa.2006.08.011. Epub 2006 Aug 30. Curr Opin Chem Biol. 2006. PMID: 16939713 Review.

4

The 'evolvability' of promiscuous protein functions.

Aharoni A, Gaidukov L, Khersonsky O, McQ Gould S, Roodveldt C, Tawfik DS. Aharoni A, et al. Among authors: roodveldt c. Nat Genet. 2005 Jan;37(1):73-6. doi: 10.1038/ng1482. Epub 2004 Nov 28. Nat Genet. 2005. PMID: 15568024

5

Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.

Roodveldt C, Tawfik DS. Roodveldt C, et al. Biochemistry. 2005 Sep 27;44(38):12728-36. doi: 10.1021/bi051021e. Biochemistry. 2005. PMID: 16171387

6

The latent promiscuity of newly identified microbial lactonases is linked to a recently diverged phosphotriesterase.

Afriat L, Roodveldt C, Manco G, Tawfik DS. Afriat L, et al. Among authors: roodveldt c. Biochemistry. 2006 Nov 21;45(46):13677-86. doi: 10.1021/bi061268r. Biochemistry. 2006. PMID: 17105187

7

A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein.

Roodveldt C, Andersson A, De Genst EJ, Labrador-Garrido A, Buell AK, Dobson CM, Tartaglia GG, Vendruscolo M. Roodveldt C, et al. Biochemistry. 2012 Nov 6;51(44):8771-8. doi: 10.1021/bi300558q. Epub 2012 Oct 22. Biochemistry. 2012. PMID: 23003198

8

Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.

Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Fernandez-Montesinos R, Caro M, Lachaud CC, Waudby CA, Delgado M, Dobson CM, Pozo D. Roodveldt C, et al. PLoS One. 2010 Oct 26;5(10):e13481. doi: 10.1371/journal.pone.0013481. PLoS One. 2010. PMID: 21048992 Free PMC article.

9

Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.

Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Lachaud CC, Guilliams T, Fernandez-Montesinos R, Benitez-Rondan A, Robledo G, Hmadcha A, Delgado M, Dobson CM, Pozo D. Roodveldt C, et al. PLoS One. 2013 Nov 13;8(11):e79160. doi: 10.1371/journal.pone.0079160. eCollection 2013. PLoS One. 2013. PMID: 24236103 Free PMC article.

10

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N. Chen SW, et al. Among authors: roodveldt c. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8. Proc Natl Acad Sci U S A. 2015. PMID: 25855634 Free PMC article.

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