Appel IM - Search Results

1

Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.

Stams WA, den Boer ML, Holleman A, Appel IM, Beverloo HB, van Wering ER, Janka-Schaub GE, Evans WE, Pieters R. Stams WA, et al. Among authors: appel im. Blood. 2005 Jun 1;105(11):4223-5. doi: 10.1182/blood-2004-10-3892. Epub 2005 Feb 17. Blood. 2005. PMID: 15718422 Free article.

2

Pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant asparaginase preparation in children with previously untreated acute lymphoblastic leukemia: a randomized phase 2 clinical trial.

Pieters R, Appel I, Kuehnel HJ, Tetzlaff-Fohr I, Pichlmeier U, van der Vaart I, Visser E, Stigter R. Pieters R, et al. Blood. 2008 Dec 15;112(13):4832-8. doi: 10.1182/blood-2008-04-149443. Epub 2008 Sep 19. Blood. 2008. PMID: 18805963 Free article. Clinical Trial.

3

Changes in hypercoagulability by asparaginase: a randomized study between two asparaginases.

Appel IM, Hop WC, Pieters R. Appel IM, et al. Blood Coagul Fibrinolysis. 2006 Mar;17(2):139-46. doi: 10.1097/01.mbc.0000214709.11492.ec. Blood Coagul Fibrinolysis. 2006. PMID: 16479196 Clinical Trial.

4

Up-regulation of asparagine synthetase expression is not linked to the clinical response L-asparaginase in pediatric acute lymphoblastic leukemia.

Appel IM, den Boer ML, Meijerink JP, Veerman AJ, Reniers NC, Pieters R. Appel IM, et al. Blood. 2006 Jun 1;107(11):4244-9. doi: 10.1182/blood-2005-06-2597. Epub 2006 Feb 23. Blood. 2006. PMID: 16497975 Free article. Clinical Trial.

5

Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study.

Appel IM, Kazemier KM, Boos J, Lanvers C, Huijmans J, Veerman AJ, van Wering E, den Boer ML, Pieters R. Appel IM, et al. Leukemia. 2008 Sep;22(9):1665-79. doi: 10.1038/leu.2008.165. Epub 2008 Jun 26. Leukemia. 2008. PMID: 18580955 Clinical Trial.

6

L-Asparaginase and the effect of age on coagulation and fibrinolysis in childhood acute lymphoblastic leukemia.

Appel IM, Hop WC, van Kessel-Bakvis C, Stigter R, Pieters R. Appel IM, et al. Thromb Haemost. 2008 Aug;100(2):330-7. Thromb Haemost. 2008. PMID: 18690355 Clinical Trial.

7

Impaired dexamethasone-related increase of anticoagulants is associated with the development of osteonecrosis in childhood acute lymphoblastic leukemia.

te Winkel ML, Appel IM, Pieters R, van den Heuvel-Eibrink MM. te Winkel ML, et al. Among authors: appel im. Haematologica. 2008 Oct;93(10):1570-4. doi: 10.3324/haematol.12956. Epub 2008 Aug 12. Haematologica. 2008. PMID: 18698082 Free article.

8

Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.

Appel IM, Pinheiro JP, den Boer ML, Lanvers C, Reniers NC, Boos J, Pieters R. Appel IM, et al. Leukemia. 2003 Nov;17(11):2254-6. doi: 10.1038/sj.leu.2403143. Leukemia. 2003. PMID: 14523472 No abstract available.

9

Influence of two different regimens of concomitant treatment with asparaginase and dexamethasone on hemostasis in childhood acute lymphoblastic leukemia.

Appel IM, van Kessel-Bakvis C, Stigter R, Pieters R. Appel IM, et al. Leukemia. 2007 Nov;21(11):2377-80. doi: 10.1038/sj.leu.2404793. Epub 2007 Jun 7. Leukemia. 2007. PMID: 17554375 No abstract available.

10

Somatic thrombopoietin (THPO) gene mutations in childhood myeloid leukemias.

Houwing ME, Koopman-Coenen EA, Kersseboom R, Gooskens S, Appel IM, Arentsen-Peters ST, de Vries AC, Reinhardt D, Stary J, Baruchel A, de Haas V, Blink M, Lopes Cardozo RH, Pieters R, Michel Zwaan C, van den Heuvel-Eibrink MM. Houwing ME, et al. Among authors: appel im. Int J Hematol. 2015 Jul;102(1):140-3. doi: 10.1007/s12185-015-1759-3. Epub 2015 Mar 3. Int J Hematol. 2015. PMID: 25728710

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