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The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer.
Lücking U, Jautelat R, Krüger M, Brumby T, Lienau P, Schäfer M, Briem H, Schulze J, Hillisch A, Reichel A, Wengner AM, Siemeister G. Lücking U, et al. Among authors: kruger m. ChemMedChem. 2013 Jul;8(7):1067-85. doi: 10.1002/cmdc.201300096. Epub 2013 May 13. ChemMedChem. 2013. PMID: 23671017
Phosphonate quinoxalinedione AMPA antagonists.
Turski L, Schneider HH, Neuhaus R, McDonald F, Jones GH, Löfberg B, Schweinfurth H, Huth A, Krüger M, Ottow E. Turski L, et al. Among authors: kruger m. Restor Neurol Neurosci. 2000;17(1):45-59. Restor Neurol Neurosci. 2000. PMID: 11490077
Reduced ATP turnover during hibernation in relaxed skeletal muscle.
De Napoli C, Schmidt L, Montesel M, Cussonneau L, Sanniti S, Marcucci L, Germinario E, Kindberg J, Evans AL, Gauquelin-Koch G, Narici M, Bertile F, Lefai E, Krüger M, Nogara L, Blaauw B. De Napoli C, et al. Among authors: kruger m. Nat Commun. 2025 Jan 2;16(1):80. doi: 10.1038/s41467-024-55565-4. Nat Commun. 2025. PMID: 39747078 Free PMC article.
From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling.
Brand T, Baumgarten BT, Denzinger S, Reinders Y, Kleindl M, Schanbacher C, Funk F, Gedik N, Jabbasseh M, Kleinbongard P, Dudek J, Szendroedi J, Tolstik E, Schuh K, Krüger M, Dobrev D, Cuello F, Sickmann A, Schmitt JP, Lorenz K. Brand T, et al. Among authors: kruger m. Pharmacol Res. 2024 Dec 30;211:107558. doi: 10.1016/j.phrs.2024.107558. Online ahead of print. Pharmacol Res. 2024. PMID: 39742932 Free article.
1,624 results