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Page 1
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Lange JH, van Stuivenberg HH, Coolen HK, Adolfs TJ, McCreary AC, Keizer HG, Wals HC, Veerman W, Borst AJ, de Looff W, Verveer PC, Kruse CG. Lange JH, et al. Among authors: coolen hk. J Med Chem. 2005 Mar 24;48(6):1823-38. doi: 10.1021/jm040843r. J Med Chem. 2005. PMID: 15771428
Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.
Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W, Wals HC, Stork B, Verveer PC, den Hartog AP, de Jong NM, Adolfs TJ, Hoogendoorn J, Kruse CG. Lange JH, et al. Among authors: coolen hk. J Med Chem. 2004 Jan 29;47(3):627-43. doi: 10.1021/jm031019q. J Med Chem. 2004. PMID: 14736243
Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition.
Smid P, Coolen HK, Keizer HG, van Hes R, de Moes JP, den Hartog AP, Stork B, Plekkenpol RH, Niemann LC, Stroomer CN, Tulp MT, van Stuivenberg HH, McCreary AC, Hesselink MB, Herremans AH, Kruse CG. Smid P, et al. Among authors: coolen hk. J Med Chem. 2005 Nov 3;48(22):6855-69. doi: 10.1021/jm050148z. J Med Chem. 2005. PMID: 16250644
7-Azaindole derivatives as potential partial nicotinic agonists.
Stoit AR, den Hartog AP, Mons H, van Schaik S, Barkhuijsen N, Stroomer C, Coolen HK, Reinders JH, Adolfs TJ, van der Neut M, Keizer H, Kruse CG. Stoit AR, et al. Among authors: coolen hk. Bioorg Med Chem Lett. 2008 Jan 1;18(1):188-93. doi: 10.1016/j.bmcl.2007.10.101. Epub 2007 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18006307