Hamada Y - Search Results

1

No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions.

Skwarczynski M, Sohma Y, Noguchi M, Kimura M, Hayashi Y, Hamada Y, Kimura T, Kiso Y. Skwarczynski M, et al. Among authors: hamada y. J Med Chem. 2005 Apr 7;48(7):2655-66. doi: 10.1021/jm049344g. J Med Chem. 2005. PMID: 15801856

2

New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.

Hamada Y, Ohtake J, Sohma Y, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Bioorg Med Chem. 2002 Dec;10(12):4155-67. doi: 10.1016/s0968-0896(02)00322-x. Bioorg Med Chem. 2002. PMID: 12413869

3

Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor.

Hamada Y, Matsumoto H, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2727-30. doi: 10.1016/s0960-894x(03)00576-6. Bioorg Med Chem Lett. 2003. PMID: 12873502

4

A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel.

Hayashi Y, Skwarczynski M, Hamada Y, Sohma Y, Kimura T, Kiso Y. Hayashi Y, et al. Among authors: hamada y. J Med Chem. 2003 Aug 28;46(18):3782-4. doi: 10.1021/jm034112n. J Med Chem. 2003. PMID: 12930140

5

Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.

Hamada Y, Matsumoto H, Yamaguchi S, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Bioorg Med Chem. 2004 Jan 2;12(1):159-70. doi: 10.1016/j.bmc.2003.10.026. Bioorg Med Chem. 2004. PMID: 14697781

6

O-N intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides.

Sohma Y, Hayashi Y, Skwarczynski M, Hamada Y, Sasaki M, Kimura T, Kiso Y. Sohma Y, et al. Among authors: hamada y. Biopolymers. 2004;76(4):344-56. doi: 10.1002/bip.20136. Biopolymers. 2004. PMID: 15386265

7

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.

Kimura T, Shuto D, Hamada Y, Igawa N, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Kiso Y. Kimura T, et al. Among authors: hamada t, hamada y. Bioorg Med Chem Lett. 2005 Jan 3;15(1):211-5. doi: 10.1016/j.bmcl.2004.09.090. Bioorg Med Chem Lett. 2005. PMID: 15582441

8

Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.

Kimura T, Hamada Y, Stochaj M, Ikari H, Nagamine A, Abdel-Rahman H, Igawa N, Hidaka K, Nguyen JT, Saito K, Hayashi Y, Kiso Y. Kimura T, et al. Among authors: hamada y. Bioorg Med Chem Lett. 2006 May 1;16(9):2380-6. doi: 10.1016/j.bmcl.2006.01.108. Epub 2006 Feb 14. Bioorg Med Chem Lett. 2006. PMID: 16481167

9

Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.

Ami E, Nakahara K, Sato A, Nguyen JT, Hidaka K, Hamada Y, Nakatani S, Kimura T, Hayashi Y, Kiso Y. Ami E, et al. Among authors: hamada y. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4213-7. doi: 10.1016/j.bmcl.2007.05.039. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17537628

10

Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.

Nakatani S, Hidaka K, Ami E, Nakahara K, Sato A, Nguyen JT, Hamada Y, Hori Y, Ohnishi N, Nagai A, Kimura T, Hayashi Y, Kiso Y. Nakatani S, et al. Among authors: hamada y. J Med Chem. 2008 May 22;51(10):2992-3004. doi: 10.1021/jm701555p. Epub 2008 Apr 22. J Med Chem. 2008. PMID: 18426195

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