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Page 1
Generation of novel landomycins M and O through targeted gene disruption.
Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Dürr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A. Luzhetskyy A, et al. Among authors: rohr j. Chembiochem. 2005 Apr;6(4):675-8. doi: 10.1002/cbic.200400316. Chembiochem. 2005. PMID: 15812784
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
Zhu L, Ostash B, Rix U, Nur-E-Alam M, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J. Zhu L, et al. Among authors: rohr j. J Org Chem. 2005 Jan 21;70(2):631-8. doi: 10.1021/jo0483623. J Org Chem. 2005. PMID: 15651811 Free PMC article.
Function of glycosyltransferase genes involved in urdamycin A biosynthesis.
Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A. Trefzer A, et al. Among authors: rohr j. Chem Biol. 2000 Feb;7(2):133-42. doi: 10.1016/s1074-5521(00)00079-x. Chem Biol. 2000. PMID: 10662691
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.
Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Dräger G, Kirschning A, Fischer C, Künzel E, Bearden D, Rohr J, Bechthold A. Hoffmeister D, et al. Among authors: rohr j. Chem Biol. 2000 Nov;7(11):821-31. doi: 10.1016/s1074-5521(00)00029-6. Chem Biol. 2000. PMID: 11094336
586 results