Pearson J - Search Results

1

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: pearson j. Hum Mol Genet. 2005 May 15;14(10):1379-92. doi: 10.1093/hmg/ddi147. Epub 2005 Apr 13. Hum Mol Genet. 2005. PMID: 15829505

2

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: pearson j. J Neurosci. 2005 Apr 20;25(16):4169-80. doi: 10.1523/JNEUROSCI.0590-05.2005. J Neurosci. 2005. PMID: 15843620 Free PMC article.

3

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: pearson j. Exp Neurol. 2005 Dec;196(2):266-72. doi: 10.1016/j.expneurol.2005.07.021. Epub 2005 Aug 29. Exp Neurol. 2005. PMID: 16129433

4

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: pearson j. J Neurochem. 2005 Oct;95(1):210-20. doi: 10.1111/j.1471-4159.2005.03357.x. J Neurochem. 2005. PMID: 16181425 Free article.

5

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Graham RK, et al. Among authors: pearson j. Neurobiol Dis. 2006 Feb;21(2):444-55. doi: 10.1016/j.nbd.2005.08.007. Epub 2005 Oct 17. Neurobiol Dis. 2006. PMID: 16230019

6

Body weight is modulated by levels of full-length huntingtin.

Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: pearson j. Hum Mol Genet. 2006 May 1;15(9):1513-23. doi: 10.1093/hmg/ddl072. Epub 2006 Mar 28. Hum Mol Genet. 2006. PMID: 16571604

7

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Among authors: pearson j. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

8

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: pearson j. BMC Neurosci. 2006 Dec 5;7:80. doi: 10.1186/1471-2202-7-80. BMC Neurosci. 2006. PMID: 17147801 Free PMC article.

9

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.

Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: pearson j. Neurobiol Dis. 2007 Apr;26(1):189-200. doi: 10.1016/j.nbd.2006.12.010. Epub 2006 Dec 29. Neurobiol Dis. 2007. PMID: 17276692

10

Testicular degeneration in Huntington disease.

Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: pearson j. Neurobiol Dis. 2007 Jun;26(3):512-20. doi: 10.1016/j.nbd.2007.01.006. Epub 2007 Jan 27. Neurobiol Dis. 2007. PMID: 17433700

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