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Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P. Lackner MR, et al. Among authors: brown k. Cancer Cell. 2005 Apr;7(4):325-36. doi: 10.1016/j.ccr.2005.03.024. Cancer Cell. 2005. PMID: 15837622 Free article.
Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.
Zhang P, Kitchen-Smith I, Xiong L, Stracquadanio G, Brown K, Richter PH, Wallace MD, Bond E, Sahgal N, Moore S, Nornes S, De Val S, Surakhy M, Sims D, Wang X, Bell DA, Zeron-Medina J, Jiang Y, Ryan AJ, Selfe JL, Shipley J, Kar S, Pharoah PD, Loveday C, Jansen R, Grochola LF, Palles C, Protheroe A, Millar V, Ebner DV, Pagadala M, Blagden SP, Maughan TS, Domingo E, Tomlinson I, Turnbull C, Carter H, Bond GL. Zhang P, et al. Among authors: brown k. Cancer Res. 2021 Apr 1;81(7):1667-1680. doi: 10.1158/0008-5472.CAN-20-0177. Epub 2021 Feb 8. Cancer Res. 2021. PMID: 33558336 Free PMC article.
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Hobor S, Al Bakir M, Hiley CT, Skrzypski M, Frankell AM, Bakker B, Watkins TBK, Markovets A, Dry JR, Brown AP, van der Aart J, van den Bos H, Spierings D, Oukrif D, Novelli M, Chakrabarti T, Rabinowitz AH, Ait Hassou L, Litière S, Kerr DL, Tan L, Kelly G, Moore DA, Renshaw MJ, Venkatesan S, Hill W, Huebner A, Martínez-Ruiz C, Black JRM, Wu W, Angelova M, McGranahan N, Downward J, Chmielecki J, Barrett C, Litchfield K, Chew SK, Blakely CM, de Bruin EC, Foijer F, Vousden KH, Bivona TG; TRACERx consortium; Hynds RE, Kanu N, Zaccaria S, Grönroos E, Swanton C. Hobor S, et al. Among authors: brown ap. Nat Commun. 2024 Jun 13;15(1):4871. doi: 10.1038/s41467-024-47606-9. Nat Commun. 2024. PMID: 38871738 Free PMC article.
Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA.
Tanu T, Cox AM, Karlow J, Sharma P, He X, Wu C, Babu S, Brown J, Brown KM, Chanock SJ, Liu D, Zhang T, Burns KH, Boutz PL, Insco ML. Tanu T, et al. Among authors: brown km. bioRxiv [Preprint]. 2025 Jan 14:2025.01.10.632423. doi: 10.1101/2025.01.10.632423. bioRxiv. 2025. PMID: 39868094 Free PMC article. Preprint.
Establishing a Pan-European, multi-disciplinary taphonomic research Infrastructure: The 'UK-Netherlands decomposition experimental research (UNDER) Group'.
Brooks J, Jantzi A, Brown K, Birch W, Nijeholt LLA, Rogers C, Mickleburgh H, Randolph-Quinney P, Kootker L, Aalders M, Oostra RJ, Williams A, Hiley C, Everett J, Cassella JP. Brooks J, et al. Among authors: brown k. Sci Justice. 2025 Jan;65(1):62-69. doi: 10.1016/j.scijus.2024.12.007. Epub 2024 Dec 28. Sci Justice. 2025. PMID: 39855772 Free article.
The impact of imprecise case definitions in electronic health record research: a melanoma case-study from the Million Veteran Program.
Wheless L, Mosley D, Dochtermann D, Pyarajan S, Gonzalez K, Weiss R, Maas K, Zhang S, Yao L, Xu Y, Madden C, Ike J, Smith IT, Grossarth S, Wilson O, Hung A, Fillmore NR, Brown K, Landi MT, Hartman RI; VA Million Veteran Program. Wheless L, et al. Among authors: brown k. Arch Dermatol Res. 2025 Jan 24;317(1):308. doi: 10.1007/s00403-024-03780-w. Arch Dermatol Res. 2025. PMID: 39853431
8,975 results