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In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA.
Mallon PW, Unemori P, Sedwell R, Morey A, Rafferty M, Williams K, Chisholm D, Samaras K, Emery S, Kelleher A, Cooper DA, Carr A; SAMA Investigators. Mallon PW, et al. Among authors: sedwell r. J Infect Dis. 2005 May 15;191(10):1686-96. doi: 10.1086/429697. Epub 2005 Apr 12. J Infect Dis. 2005. PMID: 15838796
Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene expression in human adipose tissue is limited by antiretroviral drug-induced mitochondrial dysfunction.
Mallon PW, Sedwell R, Rogers G, Nolan D, Unemori P, Hoy J, Samaras K, Kelleher A, Emery S, Cooper DA, Carr A; Rosey Investigators. Mallon PW, et al. Among authors: sedwell r. J Infect Dis. 2008 Dec 15;198(12):1794-803. doi: 10.1086/593179. J Infect Dis. 2008. PMID: 18954260 Clinical Trial.