Hansen H - Search Results

1

The fully human anti-CD30 antibody 5F11 activates NF-{kappa}B and sensitizes lymphoma cells to bortezomib-induced apoptosis.

Böll B, Hansen H, Heuck F, Reiners K, Borchmann P, Rothe A, Engert A, Pogge von Strandmann E. Böll B, et al. Among authors: hansen h. Blood. 2005 Sep 1;106(5):1839-42. doi: 10.1182/blood-2005-01-0427. Epub 2005 May 5. Blood. 2005. PMID: 15878978 Free article.

2

The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma.

Borchmann P, Treml JF, Hansen H, Gottstein C, Schnell R, Staak O, Zhang HF, Davis T, Keler T, Diehl V, Graziano RF, Engert A. Borchmann P, et al. Among authors: hansen h. Blood. 2003 Nov 15;102(10):3737-42. doi: 10.1182/blood-2003-02-0515. Epub 2003 Jul 24. Blood. 2003. PMID: 12881320 Free article.

3

Combination of the human anti-CD30 antibody 5F11 with cytostatic drugs enhances its antitumor activity against Hodgkin and anaplastic large cell lymphoma cell lines.

Heuck F, Ellermann J, Borchmann P, Rothe A, Hansen H, Engert A, von Strandmann EP. Heuck F, et al. Among authors: hansen h. J Immunother. 2004 Sep-Oct;27(5):347-53. doi: 10.1097/00002371-200409000-00003. J Immunother. 2004. PMID: 15314543

4

A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.

von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A. von Strandmann EP, et al. Blood. 2006 Mar 1;107(5):1955-62. doi: 10.1182/blood-2005-05-2177. Epub 2005 Oct 6. Blood. 2006. PMID: 16210338 Free article.

5

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity.

Reiners KS, Topolar D, Henke A, Simhadri VR, Kessler J, Sauer M, Bessler M, Hansen HP, Tawadros S, Herling M, Krönke M, Hallek M, Pogge von Strandmann E. Reiners KS, et al. Blood. 2013 May 2;121(18):3658-65. doi: 10.1182/blood-2013-01-476606. Epub 2013 Mar 18. Blood. 2013. PMID: 23509156 Free PMC article.

6

TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.

Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell HW, Rose-John S, Engert A, von Strandmann EP, Hansen HP. Vahdat AM, et al. Among authors: hansen hp. Leukemia. 2010 Jan;24(1):51-7. doi: 10.1038/leu.2009.230. Epub 2009 Nov 5. Leukemia. 2010. PMID: 19890373

7

A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma.

Schnell R, Staak O, Borchmann P, Schwartz C, Matthey B, Hansen H, Schindler J, Ghetie V, Vitetta ES, Diehl V, Engert A. Schnell R, et al. Among authors: hansen h. Clin Cancer Res. 2002 Jun;8(6):1779-86. Clin Cancer Res. 2002. PMID: 12060617 Clinical Trial.

8

Treatment of refractory Hodgkin's lymphoma patients with an iodine-131-labeled murine anti-CD30 monoclonal antibody.

Schnell R, Dietlein M, Staak JO, Borchmann P, Schomaecker K, Fischer T, Eschner W, Hansen H, Morschhauser F, Schicha H, Diehl V, Raubitschek A, Engert A. Schnell R, et al. Among authors: hansen h. J Clin Oncol. 2005 Jul 20;23(21):4669-78. doi: 10.1200/JCO.2005.09.098. J Clin Oncol. 2005. PMID: 16034043

9

The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5.

Hansen HP, Recke A, Reineke U, Von Tresckow B, Borchmann P, Von Strandmann EP, Lange H, Lemke H, Engert A. Hansen HP, et al. FASEB J. 2004 May;18(7):893-5. doi: 10.1096/fj.03-0901fje. Epub 2004 Mar 19. FASEB J. 2004. PMID: 15033921

10

Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.

von Tresckow B, Kallen KJ, von Strandmann EP, Borchmann P, Lange H, Engert A, Hansen HP. von Tresckow B, et al. Among authors: hansen hp. J Immunol. 2004 Apr 1;172(7):4324-31. doi: 10.4049/jimmunol.172.7.4324. J Immunol. 2004. PMID: 15034047

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