Hume WE - Search Results

1

SMP-534 inhibits TGF-beta-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis.

Sugaru E, Sakai M, Horigome K, Tokunaga T, Kitoh M, Hume WE, Nagata R, Nakagawa T, Taiji M. Sugaru E, et al. Among authors: hume we. Am J Physiol Renal Physiol. 2005 Nov;289(5):F998-1004. doi: 10.1152/ajprenal.00065.2005. Epub 2005 May 17. Am J Physiol Renal Physiol. 2005. PMID: 15900023 Free article.

2

SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: hume we. Am J Physiol Renal Physiol. 2006 Apr;290(4):F813-20. doi: 10.1152/ajprenal.00357.2005. Epub 2005 Nov 8. Am J Physiol Renal Physiol. 2006. PMID: 16278277 Free article.

3

Structure-activity relationships of the oxindole growth hormone secretagogues.

Tokunaga T, Hume WE, Nagamine J, Kawamura T, Taiji M, Nagata R. Tokunaga T, et al. Among authors: hume we. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1789-92. doi: 10.1016/j.bmcl.2005.02.042. Bioorg Med Chem Lett. 2005. PMID: 15780607

4

Enhanced effect of combined treatment with SMP-534 (antifibrotic agent) and losartan in diabetic nephropathy.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: hume we. Am J Nephrol. 2006;26(1):50-8. doi: 10.1159/000091786. Epub 2006 Feb 24. Am J Nephrol. 2006. PMID: 16508247

5

Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686.

Nagamine J, Kawamura T, Tokunaga T, Hume WE, Nagata R, Nakagawa T, Taiji M. Nagamine J, et al. Among authors: hume we. Comb Chem High Throughput Screen. 2006 Mar;9(3):187-96. doi: 10.2174/138620706776055548. Comb Chem High Throughput Screen. 2006. PMID: 16533152 Review.

6

Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice.

Sugaru E, Nakagawa T, Ono-Kishino M, Nagamine J, Tokunaga T, Kitoh M, Hume WE, Nagata R, Taiji M. Sugaru E, et al. Among authors: hume we. Nephron Exp Nephrol. 2007;105(2):e45-52. doi: 10.1159/000097603. Epub 2006 Nov 30. Nephron Exp Nephrol. 2007. PMID: 17139189

7

Oxindole derivatives as orally active potent growth hormone secretagogues.

Tokunaga T, Hume WE, Umezome T, Okazaki K, Ueki Y, Kumagai K, Hourai S, Nagamine J, Seki H, Taiji M, Noguchi H, Nagata R. Tokunaga T, et al. Among authors: hume we. J Med Chem. 2001 Dec 20;44(26):4641-9. doi: 10.1021/jm0103763. J Med Chem. 2001. PMID: 11741481

8

The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.

Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y, Watanabe Y. Hume WE, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7584-90. doi: 10.1016/j.bmc.2013.10.041. Epub 2013 Nov 1. Bioorg Med Chem. 2013. PMID: 24238901

9

Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse.

Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y. Shingaki T, et al. Among authors: hume we. Pharm Res. 2015 Aug;32(8):2538-47. doi: 10.1007/s11095-015-1642-1. Epub 2015 Feb 27. Pharm Res. 2015. PMID: 25715695

10

¹⁸F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation.

Nozaki S, Nakatani Y, Mawatari A, Shibata N, Hume WE, Hayashinaka E, Wada Y, Doi H, Watanabe Y. Nozaki S, et al. Among authors: hume we. Sci Rep. 2019 Oct 31;9(1):15718. doi: 10.1038/s41598-019-52270-x. Sci Rep. 2019. PMID: 31673030 Free PMC article.

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