Kachler S - Search Results

1

Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists.

Pastorin G, Bolcato C, Cacciari B, Kachler S, Klotz KN, Montopoli C, Moro S, Spalluto G. Pastorin G, et al. Among authors: kachler s. Farmaco. 2005 Aug;60(8):643-51. doi: 10.1016/j.farmac.2005.04.012. Farmaco. 2005. PMID: 15961085

2

2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors.

Klotz KN, Camaioni E, Volpini R, Kachler S, Vittori S, Cristalli G. Klotz KN, et al. Among authors: kachler s. Naunyn Schmiedebergs Arch Pharmacol. 1999 Aug;360(2):103-8. doi: 10.1007/s002109900044. Naunyn Schmiedebergs Arch Pharmacol. 1999. PMID: 10494877

3

Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists.

Pastorin G, Bolcato C, Cacciari B, Kachler S, Klotz KN, Montopoli C, Moro S, Spalluto G. Pastorin G, et al. Among authors: kachler s. Farmaco. 2005 Apr;60(4):299-306. doi: 10.1016/j.farmac.2005.01.008. Farmaco. 2005. PMID: 15848204

4

Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.

Michielan L, Bolcato C, Federico S, Cacciari B, Bacilieri M, Klotz KN, Kachler S, Pastorin G, Cardin R, Sperduti A, Spalluto G, Moro S. Michielan L, et al. Among authors: kachler s. Bioorg Med Chem. 2009 Jul 15;17(14):5259-74. doi: 10.1016/j.bmc.2009.05.038. Epub 2009 May 21. Bioorg Med Chem. 2009. PMID: 19501513

5

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.

Cheong SL, Dolzhenko A, Kachler S, Paoletta S, Federico S, Cacciari B, Dolzhenko A, Klotz KN, Moro S, Spalluto G, Pastorin G. Cheong SL, et al. Among authors: kachler s. J Med Chem. 2010 Apr 22;53(8):3361-75. doi: 10.1021/jm100049f. J Med Chem. 2010. PMID: 20307065

6

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

Cheong SL, Dolzhenko AV, Paoletta S, Lee EP, Kachler S, Federico S, Klotz KN, Dolzhenko AV, Spalluto G, Moro S, Pastorin G. Cheong SL, et al. Among authors: kachler s. Bioorg Med Chem. 2011 Oct 15;19(20):6120-34. doi: 10.1016/j.bmc.2011.08.026. Epub 2011 Aug 23. Bioorg Med Chem. 2011. PMID: 21908194

7

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold.

Gaspar A, Reis J, Kachler S, Paoletta S, Uriarte E, Klotz KN, Moro S, Borges F. Gaspar A, et al. Among authors: kachler s. Biochem Pharmacol. 2012 Jul 1;84(1):21-9. doi: 10.1016/j.bcp.2012.03.007. Epub 2012 Mar 17. Biochem Pharmacol. 2012. PMID: 22433284

8

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.

Inamdar GS, Pandya AN, Thakar HM, Sudarsanam V, Kachler S, Sabbadin D, Moro S, Klotz KN, Vasu KK. Inamdar GS, et al. Among authors: kachler s. Eur J Med Chem. 2013 May;63:924-34. doi: 10.1016/j.ejmech.2013.03.020. Epub 2013 Mar 22. Eur J Med Chem. 2013. PMID: 23685887

9

Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity.

Yadav R, Bansal R, Kachler S, Klotz KN. Yadav R, et al. Among authors: kachler s. Eur J Med Chem. 2014 Mar 21;75:327-35. doi: 10.1016/j.ejmech.2014.01.045. Epub 2014 Jan 30. Eur J Med Chem. 2014. PMID: 24556147

10

The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.

Federico S, Redenti S, Sturlese M, Ciancetta A, Kachler S, Klotz KN, Cacciari B, Moro S, Spalluto G. Federico S, et al. Among authors: kachler s. PLoS One. 2015 Dec 1;10(12):e0143504. doi: 10.1371/journal.pone.0143504. eCollection 2015. PLoS One. 2015. PMID: 26625265 Free PMC article.

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