Lynch D - Search Results

1

Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.

Barnett-Norris J, Lynch D, Reggio PH. Barnett-Norris J, et al. Among authors: lynch d. Life Sci. 2005 Aug 19;77(14):1625-39. doi: 10.1016/j.lfs.2005.05.040. Life Sci. 2005. PMID: 15993425 Review.

2

Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics.

Lynch DL, Reggio PH. Lynch DL, et al. J Med Chem. 2005 Jul 28;48(15):4824-33. doi: 10.1021/jm058185d. J Med Chem. 2005. PMID: 16033262

3

Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer.

Lynch DL, Reggio PH. Lynch DL, et al. J Comput Aided Mol Des. 2006 Jul-Aug;20(7-8):495-509. doi: 10.1007/s10822-006-9068-9. Epub 2006 Nov 14. J Comput Aided Mol Des. 2006. PMID: 17106765

4

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA. Laprairie RB, et al. Among authors: lynch d. ACS Chem Neurosci. 2016 Jun 15;7(6):776-98. doi: 10.1021/acschemneuro.6b00041. Epub 2016 Apr 25. ACS Chem Neurosci. 2016. PMID: 27046127 Free PMC article.

5

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.

Singh R, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Guarnieri F. Singh R, et al. Among authors: lynch dl. J Pept Res. 2002 Dec;60(6):357-70. doi: 10.1034/j.1399-3011.2002.21065.x. J Pept Res. 2002. PMID: 12464114

6

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.

Barnett-Norris J, Hurst DP, Lynch DL, Guarnieri F, Makriyannis A, Reggio PH. Barnett-Norris J, et al. J Med Chem. 2002 Aug 15;45(17):3649-59. doi: 10.1021/jm0200761. J Med Chem. 2002. PMID: 12166938

7

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.

Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH. Hurst DP, et al. Among authors: lynch dl. J Biol Chem. 2010 Jun 4;285(23):17954-64. doi: 10.1074/jbc.M109.041590. Epub 2010 Mar 10. J Biol Chem. 2010. PMID: 20220143 Free PMC article.

8

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

Kotsikorou E, Lynch DL, Abood ME, Reggio PH. Kotsikorou E, et al. Chem Phys Lipids. 2011 Feb;164(2):131-43. doi: 10.1016/j.chemphyslip.2010.12.003. Epub 2010 Dec 24. Chem Phys Lipids. 2011. PMID: 21185816 Free PMC article.

9

Parameterization of Org27569: an allosteric modulator of the cannabinoid CB1 G protein-coupled receptor.

Iliff HA, Lynch DL, Kotsikorou E, Reggio PH. Iliff HA, et al. J Comput Chem. 2011 Jul 30;32(10):2119-26. doi: 10.1002/jcc.21794. Epub 2011 Apr 27. J Comput Chem. 2011. PMID: 21523790 Free PMC article.

10

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Madrigal KE, Hurst DP, Sharir H, Lynch DL, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak L, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: lynch dl. Biochemistry. 2011 Jun 28;50(25):5633-47. doi: 10.1021/bi200010k. Epub 2011 Jun 1. Biochemistry. 2011. PMID: 21534610 Free PMC article.

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