Khatib AM - Search Results

1

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.

Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM. Siegfried G, et al. Among authors: khatib am. Oncogene. 2005 Oct 20;24(46):6925-35. doi: 10.1038/sj.onc.1208838. Oncogene. 2005. PMID: 16007151

2

Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions.

Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. J Biol Chem. 2001 Aug 17;276(33):30686-93. doi: 10.1074/jbc.M101725200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402025 Free article.

3

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.

Khatib AM, Siegfried G, Chrétien M, Metrakos P, Seidah NG. Khatib AM, et al. Am J Pathol. 2002 Jun;160(6):1921-35. doi: 10.1016/S0002-9440(10)61140-6. Am J Pathol. 2002. PMID: 12057895 Free PMC article. Review.

4

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

Siegfried G, Khatib AM, Benjannet S, Chrétien M, Seidah NG. Siegfried G, et al. Among authors: khatib am. Cancer Res. 2003 Apr 1;63(7):1458-63. Cancer Res. 2003. PMID: 12670890

5

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. Siegfried G, et al. Among authors: khatib am. J Clin Invest. 2003 Jun;111(11):1723-32. doi: 10.1172/JCI17220. J Clin Invest. 2003. PMID: 12782675 Free PMC article.

6

Endo/exo-proteolysis in neoplastic progression and metastasis.

Khatib AM, Bassi D, Siegfried G, Klein-Szanto AJ, Ouafik L. Khatib AM, et al. J Mol Med (Berl). 2005 Nov;83(11):856-64. doi: 10.1007/s00109-005-0692-y. Epub 2005 Aug 26. J Mol Med (Berl). 2005. PMID: 16133424 Review.

7

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.

Tzimas GN, Chevet E, Jenna S, Nguyên DT, Khatib AM, Marcus V, Zhang Y, Chrétien M, Seidah N, Metrakos P. Tzimas GN, et al. Among authors: khatib am. BMC Cancer. 2005 Nov 17;5:149. doi: 10.1186/1471-2407-5-149. BMC Cancer. 2005. PMID: 16293189 Free PMC article.

8

The proprotein convertases and their implication in sterol and/or lipid metabolism.

Seidah NG, Khatib AM, Prat A. Seidah NG, et al. Among authors: khatib am. Biol Chem. 2006 Jul;387(7):871-7. doi: 10.1515/BC.2006.110. Biol Chem. 2006. PMID: 16913836 Review.

9

Proprotein convertases: lessons from knockouts.

Scamuffa N, Calvo F, Chrétien M, Seidah NG, Khatib AM. Scamuffa N, et al. Among authors: khatib am. FASEB J. 2006 Oct;20(12):1954-63. doi: 10.1096/fj.05-5491rev. FASEB J. 2006. PMID: 17012247 Review.

10

Potential opportunity in the development of new therapeutic agents based on endogenous and exogenous inhibitors of the proprotein convertases.

Bontemps Y, Scamuffa N, Calvo F, Khatib AM. Bontemps Y, et al. Among authors: khatib am. Med Res Rev. 2007 Sep;27(5):631-48. doi: 10.1002/med.20072. Med Res Rev. 2007. PMID: 17019676 Free PMC article. Review.

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