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Neurotoxic protein oligomers--what you see is not always what you get.
Amyloid. 2005 Jun;12(2):88-95. doi: 10.1080/13506120500106958.
Amyloid. 2005.
PMID: 16011984
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.
Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G.
Fradinger EA, et al. Among authors: spring sm.
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14175-80. doi: 10.1073/pnas.0807163105. Epub 2008 Sep 8.
Proc Natl Acad Sci U S A. 2008.
PMID: 18779585
Free PMC article.
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Amino acid position-specific contributions to amyloid beta-protein oligomerization.
Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB.
Maji SK, et al. Among authors: spring sm.
J Biol Chem. 2009 Aug 28;284(35):23580-91. doi: 10.1074/jbc.M109.038133. Epub 2009 Jun 30.
J Biol Chem. 2009.
PMID: 19567875
Free PMC article.
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Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.
Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G.
Li H, et al. Among authors: spring sm.
Biochemistry. 2010 Aug 3;49(30):6358-64. doi: 10.1021/bi100773g.
Biochemistry. 2010.
PMID: 20568734
Free PMC article.
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