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Page 1
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
Bueno AB, Collado I, de Dios A, Domínguez C, Martín JA, Martín LM, Martínez-Grau MA, Montero C, Pedregal C, Catlow J, Coffey DS, Clay MP, Dantzig AH, Lindstrom T, Monn JA, Jiang H, Schoepp DD, Stratford RE, Tabas LB, Tizzano JP, Wright RA, Herin MF. Bueno AB, et al. Among authors: collado i. J Med Chem. 2005 Aug 11;48(16):5305-20. doi: 10.1021/jm050235r. J Med Chem. 2005. PMID: 16078848
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.
Collado I, Pedregal C, Bueno AB, Marcos A, González R, Blanco-Urgoiti J, Pérez-Castells J, Schoepp DD, Wright RA, Johnson BG, Kingston AE, Moher ED, Hoard DW, Griffey KI, Tizzano JP. Collado I, et al. J Med Chem. 2004 Jan 15;47(2):456-66. doi: 10.1021/jm030967o. J Med Chem. 2004. PMID: 14711315
C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies.
González R, Collado I, de Uralde BL, Marcos A, Martín-Cabrejas LM, Pedregal C, Blanco-Urgoiti J, Pérez-Castells J, Fernández MA, Andis SL, Johnson BG, Wright RA, Schoepp DD, Monn JA. González R, et al. Among authors: collado i. Bioorg Med Chem. 2005 Dec 1;13(23):6556-70. doi: 10.1016/j.bmc.2005.07.036. Epub 2005 Sep 8. Bioorg Med Chem. 2005. PMID: 16153851
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Baker SR, Bleakman D, Ezquerra J, Ballyk BA, Deverill M, Ho K, Kamboj RK, Collado I, Domínguez C, Escribano A, Mateo AI, Pedregal C, Rubio A. Baker SR, et al. Among authors: collado i. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1807-10. doi: 10.1016/s0960-894x(00)00346-2. Bioorg Med Chem Lett. 2000. PMID: 10969973
Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.
Fisher MJ, Backer RT, Collado I, de Frutos O, Husain S, Hsiung HM, Kuklish SL, Mateo AI, Mullaney JT, Ornstein PL, Paredes CG, O'Brian TP, Richardson TI, Shah J, Zgombick JM, Briner K. Fisher MJ, et al. Among authors: collado i. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4973-8. doi: 10.1016/j.bmcl.2005.08.018. Bioorg Med Chem Lett. 2005. PMID: 16169215
136 results