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Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.
Nguyen BT, Marc A, Suñer C, Marks M, Ubals M, Hernández-Rodríguez Á, Melendez MÁ; Movie Group; Hruby DE, Russo AT, Mentré F, Mitjà O, Grosenbach DW, Guedj J. Nguyen BT, et al. Among authors: hruby de. PLoS Biol. 2023 Dec 21;21(12):e3002249. doi: 10.1371/journal.pbio.3002249. eCollection 2023 Dec. PLoS Biol. 2023. PMID: 38127878 Free PMC article.
Emerging pharmacological strategies for treating and preventing mpox.
Grosenbach DW, Russo AT, Blum ED, Hruby DE. Grosenbach DW, et al. Among authors: hruby de. Expert Rev Clin Pharmacol. 2023 Jul-Dec;16(9):843-854. doi: 10.1080/17512433.2023.2249820. Epub 2023 Aug 22. Expert Rev Clin Pharmacol. 2023. PMID: 37592723 Review.
In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat.
Nunes DDS, Higa LM, Oliveira RL, da Costa LC, Bomfim LM, Gonçalves CCA, Mariani D, Hruby DE, Voloch CM, Castiñeiras TMPP, Tanuri A, Damaso CR. Nunes DDS, et al. Among authors: hruby de. Mem Inst Oswaldo Cruz. 2023 Jul 10;118:e230056. doi: 10.1590/0074-02760230056. eCollection 2023. Mem Inst Oswaldo Cruz. 2023. PMID: 37436275 Free PMC article.
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential.
Russo AT, Grosenbach DW, Honeychurch KM, Long PG, Hruby DE. Russo AT, et al. Among authors: hruby de. Expert Rev Anti Infect Ther. 2023 Mar;21(3):235-242. doi: 10.1080/14787210.2023.2170350. Epub 2023 Feb 2. Expert Rev Anti Infect Ther. 2023. PMID: 36728515 Free PMC article.
Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
Frenois-Veyrat G, Gallardo F, Gorgé O, Marcheteau E, Ferraris O, Baidaliuk A, Favier AL, Enfroy C, Holy X, Lourenco J, Khoury R, Nolent F, Grosenbach DW, Hruby DE, Ferrier A, Iseni F, Simon-Loriere E, Tournier JN. Frenois-Veyrat G, et al. Among authors: hruby de. Nat Microbiol. 2022 Dec;7(12):1951-1955. doi: 10.1038/s41564-022-01269-8. Epub 2022 Nov 7. Nat Microbiol. 2022. PMID: 36344621
Clinical features and management of human monkeypox: a retrospective observational study in the UK.
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network. Adler H, et al. Lancet Infect Dis. 2022 Aug;22(8):1153-1162. doi: 10.1016/S1473-3099(22)00228-6. Epub 2022 May 24. Lancet Infect Dis. 2022. PMID: 35623380 Free PMC article.
228 results