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The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family.
Boya P, Morales MC, Gonzalez-Polo RA, Andreau K, Gourdier I, Perfettini JL, Larochette N, Deniaud A, Baran-Marszak F, Fagard R, Feuillard J, Asumendi A, Raphael M, Pau B, Brenner C, Kroemer G. Boya P, et al. Among authors: larochette n. Oncogene. 2003 Sep 18;22(40):6220-30. doi: 10.1038/sj.onc.1206827. Oncogene. 2003. PMID: 13679861
Inhibition of macroautophagy triggers apoptosis.
Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G. Boya P, et al. Among authors: larochette n. Mol Cell Biol. 2005 Feb;25(3):1025-40. doi: 10.1128/MCB.25.3.1025-1040.2005. Mol Cell Biol. 2005. PMID: 15657430 Free PMC article.
Preapoptotic chromatin condensation upstream of the mitochondrial checkpoint.
Andreau K, Castedo M, Perfettini JL, Roumier T, Pichart E, Souquere S, Vivet S, Larochette N, Kroemer G. Andreau K, et al. Among authors: larochette n. J Biol Chem. 2004 Dec 31;279(53):55937-45. doi: 10.1074/jbc.M406411200. Epub 2004 Oct 21. J Biol Chem. 2004. PMID: 15498771 Free article.
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death.
González-Polo RA, Boya P, Pauleau AL, Jalil A, Larochette N, Souquère S, Eskelinen EL, Pierron G, Saftig P, Kroemer G. González-Polo RA, et al. Among authors: larochette n. J Cell Sci. 2005 Jul 15;118(Pt 14):3091-102. doi: 10.1242/jcs.02447. Epub 2005 Jun 28. J Cell Sci. 2005. PMID: 15985464
52 results