Kellenberger E - Search Results

1

Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.

Goodrich SP, Muller-Steffner H, Osman A, Moutin MJ, Kusser K, Roberts A, Woodland DL, Randall TD, Kellenberger E, LoVerde PT, Schuber F, Lund FE. Goodrich SP, et al. Among authors: kellenberger e. Biochemistry. 2005 Aug 23;44(33):11082-97. doi: 10.1021/bi050704r. Biochemistry. 2005. PMID: 16101292

2

Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity.

Kuhn I, Kellenberger E, Rognan D, Lund FE, Muller-Steffner H, Schuber F. Kuhn I, et al. Among authors: kellenberger e. Biochemistry. 2006 Oct 3;45(39):11867-78. doi: 10.1021/bi060930g. Biochemistry. 2006. PMID: 17002287 Free PMC article.

3

Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis.

Kuhn I, Kellenberger E, Schuber F, Muller-Steffner H. Kuhn I, et al. Among authors: kellenberger e. Biochim Biophys Acta. 2013 Dec;1834(12):2520-7. doi: 10.1016/j.bbapap.2013.09.002. Epub 2013 Sep 12. Biochim Biophys Acta. 2013. PMID: 24035885

4

Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.

Jacques SA, Kuhn I, Koniev O, Schuber F, Lund FE, Wagner A, Muller-Steffner H, Kellenberger E. Jacques SA, et al. Among authors: kellenberger e. J Med Chem. 2015 Apr 23;58(8):3582-92. doi: 10.1021/acs.jmedchem.5b00203. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25803425

5

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

Kuhn I, Kellenberger E, Said-Hassane F, Villa P, Rognan D, Lobstein A, Haiech J, Hibert M, Schuber F, Muller-Steffner H. Kuhn I, et al. Among authors: kellenberger e. Bioorg Med Chem. 2010 Nov 15;18(22):7900-10. doi: 10.1016/j.bmc.2010.09.041. Epub 2010 Sep 25. Bioorg Med Chem. 2010. PMID: 20951593

6

Flavonoids as inhibitors of human CD38.

Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H. Kellenberger E, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3939-42. doi: 10.1016/j.bmcl.2011.05.022. Epub 2011 May 14. Bioorg Med Chem Lett. 2011. PMID: 21641214

7

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.

Egea PF, Muller-Steffner H, Kuhn I, Cakir-Kiefer C, Oppenheimer NJ, Stroud RM, Kellenberger E, Schuber F. Egea PF, et al. Among authors: kellenberger e. PLoS One. 2012;7(4):e34918. doi: 10.1371/journal.pone.0034918. Epub 2012 Apr 18. PLoS One. 2012. PMID: 22529956 Free PMC article.

8

Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues.

Kuhn I, Kellenberger E, Cakir-Kiefer C, Muller-Steffner H, Schuber F. Kuhn I, et al. Among authors: kellenberger e. Biochim Biophys Acta. 2014 Jul;1844(7):1317-31. doi: 10.1016/j.bbapap.2014.03.014. Epub 2014 Apr 8. Biochim Biophys Acta. 2014. PMID: 24721563

9

Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.

Muller-Steffner H, Jacques SA, Kuhn I, Schultz MD, Botta D, Osswald P, Maechling C, Lund FE, Kellenberger E. Muller-Steffner H, et al. Among authors: kellenberger e. ACS Chem Biol. 2017 Jul 21;12(7):1787-1795. doi: 10.1021/acschembio.7b00186. Epub 2017 May 17. ACS Chem Biol. 2017. PMID: 28481502

10

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Schultz MD, Dadali T, Jacques SA, Muller-Steffner H, Foote JB, Sorci L, Kellenberger E, Botta D, Lund FE. Schultz MD, et al. Among authors: kellenberger e. PLoS Pathog. 2020 May 27;16(5):e1008539. doi: 10.1371/journal.ppat.1008539. eCollection 2020 May. PLoS Pathog. 2020. PMID: 32459815 Free PMC article.

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