Koch U - Search Results

1

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand.

Gallinari P, Lahm A, Koch U, Paolini C, Nardi MC, Roscilli G, Kinzel O, Fattori D, Muraglia E, Toniatti C, Cortese R, De Francesco R, Ciliberto G. Gallinari P, et al. Among authors: koch u. Chem Biol. 2005 Aug;12(8):883-93. doi: 10.1016/j.chembiol.2005.05.018. Chem Biol. 2005. PMID: 16125100 Free article.

2

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.

Kinzel O, Fattori D, Muraglia E, Gallinari P, Nardi MC, Paolini C, Roscilli G, Toniatti C, Gonzalez Paz O, Laufer R, Lahm A, Tramontano A, Cortese R, De Francesco R, Ciliberto G, Koch U. Kinzel O, et al. Among authors: koch u. J Med Chem. 2006 Sep 7;49(18):5404-7. doi: 10.1021/jm060516e. J Med Chem. 2006. PMID: 16942012

3

Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.

Branca D, Cerretani M, Jones P, Koch U, Orvieto F, Palumbi MC, Rowley M, Toniatti C, Muraglia E. Branca D, et al. Among authors: koch u. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4042-5. doi: 10.1016/j.bmcl.2009.06.031. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19553107

4

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.

Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Nardi MC, Steinkühler C, Cortese R, Matassa V, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: koch u. J Mol Biol. 1999 Jun 4;289(2):385-96. doi: 10.1006/jmbi.1999.2746. J Mol Biol. 1999. PMID: 10366512

5

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P. Lahm A, et al. Among authors: koch u. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40. doi: 10.1073/pnas.0706487104. Epub 2007 Oct 23. Proc Natl Acad Sci U S A. 2007. PMID: 17956988 Free PMC article.

6

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures.

Orvieto F, Koch U, Matassa VG, Muraglia E. Orvieto F, et al. Among authors: koch u. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2745-8. doi: 10.1016/s0960-894x(03)00536-5. Bioorg Med Chem Lett. 2003. PMID: 12873506

7

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A. Di Marco S, et al. Among authors: koch u. J Biol Chem. 2005 Aug 19;280(33):29765-70. doi: 10.1074/jbc.M505423200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955819 Free article.

8

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.

Orvieto F, Branca D, Giomini C, Jones P, Koch U, Ontoria JM, Palumbi MC, Rowley M, Toniatti C, Muraglia E. Orvieto F, et al. Among authors: koch u. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4196-200. doi: 10.1016/j.bmcl.2009.05.113. Epub 2009 Jun 2. Bioorg Med Chem Lett. 2009. PMID: 19541484

9

Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus.

Ingallinella P, Fattori D, Altamura S, Steinkühler C, Koch U, Cicero D, Bazzo R, Cortese R, Bianchi E, Pessi A. Ingallinella P, et al. Among authors: koch u. Biochemistry. 2002 Apr 30;41(17):5483-92. doi: 10.1021/bi025603x. Biochemistry. 2002. PMID: 11969409

10

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.

Colarusso S, Koch U, Gerlach B, Steinkühler C, De Francesco R, Altamura S, Matassa VG, Narjes F. Colarusso S, et al. Among authors: koch u. J Med Chem. 2003 Jan 30;46(3):345-8. doi: 10.1021/jm025594q. J Med Chem. 2003. PMID: 12540231

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