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Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Sluis-Cremer N, Koontz D, Bassit L, Hernandez-Santiago BI, Detorio M, Rapp KL, Amblard F, Bondada L, Grier J, Coats SJ, Schinazi RF, Mellors JW. Sluis-Cremer N, et al. Antimicrob Agents Chemother. 2009 Sep;53(9):3715-9. doi: 10.1128/AAC.00392-09. Epub 2009 Jul 13. Antimicrob Agents Chemother. 2009. PMID: 19596885 Free PMC article.
Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance.
Hammond JL, Koontz DL, Bazmi HZ, Beadle JR, Hostetler SE, Kini GD, Aldern KA, Richman DD, Hostetler KY, Mellors JW. Hammond JL, et al. Among authors: koontz dl. Antimicrob Agents Chemother. 2001 Jun;45(6):1621-8. doi: 10.1128/AAC.45.6.1621-1628.2001. Antimicrob Agents Chemother. 2001. PMID: 11353603 Free PMC article.
Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.
Brehm JH, Koontz DL, Wallis CL, Shutt KA, Sanne I, Wood R, McIntyre JA, Stevens WS, Sluis-Cremer N, Mellors JW; CIPRA-SA Project 1 Study Team. Brehm JH, et al. Among authors: koontz dl. Clin Infect Dis. 2012 Sep;55(5):737-45. doi: 10.1093/cid/cis501. Epub 2012 May 22. Clin Infect Dis. 2012. PMID: 22618567 Free PMC article. Clinical Trial.
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