Gaidukov L - Search Results

1

High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I.

Gaidukov L, Tawfik DS. Gaidukov L, et al. Biochemistry. 2005 Sep 6;44(35):11843-54. doi: 10.1021/bi050862i. Biochemistry. 2005. PMID: 16128586

2

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.

Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS. Aharoni A, et al. Among authors: gaidukov l. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):482-7. doi: 10.1073/pnas.2536901100. Epub 2003 Dec 26. Proc Natl Acad Sci U S A. 2004. PMID: 14695884 Free PMC article.

3

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Harel M, et al. Among authors: gaidukov l. Nat Struct Mol Biol. 2004 May;11(5):412-9. doi: 10.1038/nsmb767. Epub 2004 Apr 18. Nat Struct Mol Biol. 2004. PMID: 15098021

4

The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux.

Rosenblat M, Gaidukov L, Khersonsky O, Vaya J, Oren R, Tawfik DS, Aviram M. Rosenblat M, et al. Among authors: gaidukov l. J Biol Chem. 2006 Mar 17;281(11):7657-65. doi: 10.1074/jbc.M512595200. Epub 2006 Jan 10. J Biol Chem. 2006. PMID: 16407304 Free article.

5

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.

Gaidukov L, Rosenblat M, Aviram M, Tawfik DS. Gaidukov L, et al. J Lipid Res. 2006 Nov;47(11):2492-502. doi: 10.1194/jlr.M600297-JLR200. Epub 2006 Aug 16. J Lipid Res. 2006. PMID: 16914770 Free article.

6

The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity.

Gaidukov L, Tawfik DS. Gaidukov L, et al. J Lipid Res. 2007 Jul;48(7):1637-46. doi: 10.1194/jlr.D600045-JLR200. Epub 2007 Apr 13. J Lipid Res. 2007. PMID: 17435182 Free article.

7

In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes.

Gaidukov L, Bar D, Yacobson S, Naftali E, Kaufman O, Tabakman R, Tawfik DS, Levy-Nissenbaum E. Gaidukov L, et al. BMC Clin Pharmacol. 2009 Nov 17;9:18. doi: 10.1186/1472-6904-9-18. BMC Clin Pharmacol. 2009. PMID: 19922610 Free PMC article.

8

ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I.

Gaidukov L, Viji RI, Yacobson S, Rosenblat M, Aviram M, Tawfik DS. Gaidukov L, et al. Biochemistry. 2010 Jan 26;49(3):532-8. doi: 10.1021/bi9013227. Biochemistry. 2010. PMID: 20025294

9

The 'evolvability' of promiscuous protein functions.

Aharoni A, Gaidukov L, Khersonsky O, McQ Gould S, Roodveldt C, Tawfik DS. Aharoni A, et al. Among authors: gaidukov l. Nat Genet. 2005 Jan;37(1):73-6. doi: 10.1038/ng1482. Epub 2004 Nov 28. Nat Genet. 2005. PMID: 15568024

10

Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase.

Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H. Amitai G, et al. Among authors: gaidukov l. FEBS J. 2006 May;273(9):1906-19. doi: 10.1111/j.1742-4658.2006.05198.x. FEBS J. 2006. PMID: 16640555 Free article.

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