Lecluyse EL - Search Results

1

Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells.

Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL. Smith CM, et al. Among authors: lecluyse el. J Pharmacol Exp Ther. 2005 Dec;315(3):1256-64. doi: 10.1124/jpet.105.090795. Epub 2005 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 16135700

2

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

Faucette SR, Wang H, Hamilton GA, Jolley SL, Gilbert D, Lindley C, Yan B, Negishi M, LeCluyse EL. Faucette SR, et al. Among authors: lecluyse el. Drug Metab Dispos. 2004 Mar;32(3):348-58. doi: 10.1124/dmd.32.3.348. Drug Metab Dispos. 2004. PMID: 14977870

3

Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers.

Smith CM, Faucette SR, Wang H, LeCluyse EL. Smith CM, et al. Among authors: lecluyse el. J Biochem Mol Toxicol. 2005;19(2):96-108. doi: 10.1002/jbt.20058. J Biochem Mol Toxicol. 2005. PMID: 15849716

4

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Faucette SR, et al. Among authors: lecluyse el. J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9. doi: 10.1124/jpet.105.098160. Epub 2006 Mar 2. J Pharmacol Exp Ther. 2006. PMID: 16513849

5

Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.

Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL. Graham RA, et al. Among authors: lecluyse el. J Biochem Mol Toxicol. 2006;20(2):69-78. doi: 10.1002/jbt.20118. J Biochem Mol Toxicol. 2006. PMID: 16615094

6

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Faucette SR, et al. Among authors: lecluyse el. J Pharmacol Exp Ther. 2007 Jan;320(1):72-80. doi: 10.1124/jpet.106.112136. Epub 2006 Oct 13. J Pharmacol Exp Ther. 2007. PMID: 17041008 Free PMC article.

7

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Wang H, et al. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28. J Biol Chem. 2004. PMID: 15123723 Free article.

8

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. Wang H, et al. Among authors: lecluyse el. J Biol Chem. 2003 Apr 18;278(16):14146-52. doi: 10.1074/jbc.M212482200. Epub 2003 Feb 5. J Biol Chem. 2003. PMID: 12571232 Free article.

9

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.

Wang H, Faucette SR, Gilbert D, Jolley SL, Sueyoshi T, Negishi M, LeCluyse EL. Wang H, et al. Among authors: lecluyse el. Drug Metab Dispos. 2003 May;31(5):620-30. doi: 10.1124/dmd.31.5.620. Drug Metab Dispos. 2003. PMID: 12695351

10

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

Wang H, LeCluyse EL. Wang H, et al. Among authors: lecluyse el. Clin Pharmacokinet. 2003;42(15):1331-57. doi: 10.2165/00003088-200342150-00003. Clin Pharmacokinet. 2003. PMID: 14674787 Review.

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