Chen J - Search Results

1

Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation.

Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen J, Gellman SH. Murray JK, et al. Among authors: chen j. J Am Chem Soc. 2005 Sep 28;127(38):13271-80. doi: 10.1021/ja052733v. J Am Chem Soc. 2005. PMID: 16173757

2

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Shaginian A, Whitby LR, Hong S, Hwang I, Farooqi B, Searcey M, Chen J, Vogt PK, Boger DL. Shaginian A, et al. Among authors: chen j. J Am Chem Soc. 2009 Apr 22;131(15):5564-72. doi: 10.1021/ja810025g. J Am Chem Soc. 2009. PMID: 19334711 Free PMC article.

3

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. Hu B, et al. Among authors: chen j. J Biol Chem. 2006 Nov 3;281(44):33030-5. doi: 10.1074/jbc.C600147200. Epub 2006 Aug 11. J Biol Chem. 2006. PMID: 16905541 Free article.

4

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J. Chen L, et al. Among authors: chen j. Mol Cancer Ther. 2005 Jun;4(6):1019-25. doi: 10.1158/1535-7163.MCT-04-0342. Mol Cancer Ther. 2005. PMID: 15956260

5

Design and synthesis of AApeptides: a new class of peptide mimics.

Hu Y, Li X, Sebti SM, Chen J, Cai J. Hu Y, et al. Among authors: chen j. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1469-71. doi: 10.1016/j.bmcl.2011.01.005. Epub 2011 Jan 7. Bioorg Med Chem Lett. 2011. PMID: 21292484

6

Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction.

Muppidi A, Li X, Chen J, Lin Q. Muppidi A, et al. Among authors: chen j. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7412-5. doi: 10.1016/j.bmcl.2011.10.009. Epub 2011 Oct 12. Bioorg Med Chem Lett. 2011. PMID: 22047690 Free PMC article.

7

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.

Madden MM, Muppidi A, Li Z, Li X, Chen J, Lin Q. Madden MM, et al. Among authors: chen j. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1472-5. doi: 10.1016/j.bmcl.2011.01.004. Epub 2011 Jan 7. Bioorg Med Chem Lett. 2011. PMID: 21277201 Free PMC article.

8

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.

Muppidi A, Wang Z, Li X, Chen J, Lin Q. Muppidi A, et al. Among authors: chen j. Chem Commun (Camb). 2011 Sep 7;47(33):9396-8. doi: 10.1039/c1cc13320a. Epub 2011 Jul 19. Chem Commun (Camb). 2011. PMID: 21773579 Free PMC article.

9

Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein-Protein Interactions.

Shi Y, Sang P, Lu J, Higbee P, Chen L, Yang L, Odom T, Daughdrill G, Chen J, Cai J. Shi Y, et al. Among authors: chen j, chen l. J Med Chem. 2020 Nov 12;63(21):13187-13196. doi: 10.1021/acs.jmedchem.0c01638. Epub 2020 Nov 3. J Med Chem. 2020. PMID: 33140956 Free PMC article.

10

α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions.

Sang P, Shi Y, Lu J, Chen L, Yang L, Borcherds W, Abdulkadir S, Li Q, Daughdrill G, Chen J, Cai J. Sang P, et al. Among authors: chen j, chen l. J Med Chem. 2020 Feb 13;63(3):975-986. doi: 10.1021/acs.jmedchem.9b00993. Epub 2020 Feb 3. J Med Chem. 2020. PMID: 31971801 Free PMC article.

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