The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.
Mateos S, Domínguez I, Cantero G, Pastor N, Campanella C, Cortés F.
Mateos S, et al. Among authors: cantero g.
Mutat Res. 2008 Sep 26;644(1-2):24-30. doi: 10.1016/j.mrfmmm.2008.06.007. Epub 2008 Jul 1.
Mutat Res. 2008.
PMID: 18640132
It has been recently proposed that hypomethylation of DNA induced by 5-azacytidine (5-azaC) leads to reduced chromatid decatenation that ends up in endoreduplication, most likely due to a failure in topo II function [S. Mateos, I. Dominguez, N. Pastor, G. Cantero, F …
It has been recently proposed that hypomethylation of DNA induced by 5-azacytidine (5-azaC) leads to reduced chromatid decatenation that end …