Thien CB - Search Results

1

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.

Thien CB, Langdon WY. Thien CB, et al. Biochem J. 2005 Oct 15;391(Pt 2):153-66. doi: 10.1042/BJ20050892. Biochem J. 2005. PMID: 16212556 Free PMC article. Review.

2

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.

Thien CB, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DD, Langdon WY. Thien CB, et al. J Exp Med. 2003 Feb 17;197(4):503-13. doi: 10.1084/jem.20021498. J Exp Med. 2003. PMID: 12591907 Free PMC article.

3

Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.

Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY. Oksvold MP, et al. Among authors: thien cb. Oncogene. 2003 Nov 20;22(52):8509-18. doi: 10.1038/sj.onc.1207117. Oncogene. 2003. PMID: 14627991

4

Negative regulation of PTK signalling by Cbl proteins.

Thien CB, Langdon WY. Thien CB, et al. Growth Factors. 2005 Jun;23(2):161-7. doi: 10.1080/08977190500153763. Growth Factors. 2005. PMID: 16019438 Review.

5

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

Thien CB, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, Langdon WY. Thien CB, et al. EMBO J. 2005 Nov 2;24(21):3807-19. doi: 10.1038/sj.emboj.7600841. Epub 2005 Oct 6. EMBO J. 2005. PMID: 16211006 Free PMC article.

6

Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.

Gustin SE, Thien CB, Langdon WY. Gustin SE, et al. Among authors: thien cb. J Immunol. 2006 Nov 1;177(9):5980-9. doi: 10.4049/jimmunol.177.9.5980. J Immunol. 2006. PMID: 17056522

7

The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.

Oksvold MP, Dagger SA, Thien CB, Langdon WY. Oksvold MP, et al. Among authors: thien cb. Mol Immunol. 2008 Feb;45(4):925-36. doi: 10.1016/j.molimm.2007.08.002. Epub 2007 Sep 14. Mol Immunol. 2008. PMID: 17868870

8

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, Langdon WY. Thien CB, et al. J Biol Chem. 2010 Apr 2;285(14):10969-81. doi: 10.1074/jbc.M109.094920. Epub 2010 Feb 4. J Biol Chem. 2010. PMID: 20133944 Free PMC article.

9

Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice.

Taylor SJ, Thien CB, Dagger SA, Duyvestyn JM, Grove CS, Lee BH, Gilliland DG, Langdon WY. Taylor SJ, et al. Among authors: thien cb. Exp Hematol. 2015 Mar;43(3):191-206.e1. doi: 10.1016/j.exphem.2014.11.009. Epub 2014 Dec 19. Exp Hematol. 2015. PMID: 25534201 Free article.

10

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

Andoniou CE, Thien CB, Langdon WY. Andoniou CE, et al. Among authors: thien cb. EMBO J. 1994 Oct 3;13(19):4515-23. doi: 10.1002/j.1460-2075.1994.tb06773.x. EMBO J. 1994. PMID: 7925293 Free PMC article.

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