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Page 1
Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.
Becker DP, Villamil CI, Barta TE, Bedell LJ, Boehm TL, Decrescenzo GA, Freskos JN, Getman DP, Hockerman S, Heintz R, Howard SC, Li MH, McDonald JJ, Carron CP, Funckes-Shippy CL, Mehta PP, Munie GE, Swearingen CA. Becker DP, et al. Among authors: barta te. J Med Chem. 2005 Oct 20;48(21):6713-30. doi: 10.1021/jm0500875. J Med Chem. 2005. PMID: 16220987
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J. Becker DP, et al. Among authors: barta te. J Med Chem. 2010 Sep 23;53(18):6653-80. doi: 10.1021/jm100669j. J Med Chem. 2010. PMID: 20726512
MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides.
Fobian YM, Freskos JN, Barta TE, Bedell LJ, Heintz R, Kassab DJ, Kiefer JR, Mischke BV, Molyneaux JM, Mullins P, Munie GE, Becker DP. Fobian YM, et al. Among authors: barta te. Bioorg Med Chem Lett. 2011 May 15;21(10):2823-5. doi: 10.1016/j.bmcl.2011.03.095. Epub 2011 Apr 1. Bioorg Med Chem Lett. 2011. PMID: 21493063
Synthesis and activity of selective MMP inhibitors with an aryl backbone.
Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Munie GE, Rao S, Shieh HS, Stegeman R, Stevens AM, Villamil CI. Barta TE, et al. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2815-7. doi: 10.1016/s0960-894x(00)00584-9. Bioorg Med Chem Lett. 2000. PMID: 11133099
Selective, orally active MMP inhibitors with an aryl backbone.
Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Mehta P, Munie GE, Villamil CI. Barta TE, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2481-3. doi: 10.1016/s0960-894x(01)00487-5. Bioorg Med Chem Lett. 2001. PMID: 11549451
alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.
Becker DP, Barta TE, Bedell L, DeCrescenzo G, Freskos J, Getman DP, Hockerman SL, Li M, Mehta P, Mischke B, Munie GE, Swearingen C, Villamil CI. Becker DP, et al. Among authors: barta te. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2719-22. doi: 10.1016/s0960-894x(01)00556-x. Bioorg Med Chem Lett. 2001. PMID: 11591509
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Huang KH, Veal JM, Fadden RP, Rice JW, Eaves J, Strachan JP, Barabasz AF, Foley BE, Barta TE, Ma W, Silinski MA, Hu M, Partridge JM, Scott A, DuBois LG, Freed T, Steed PM, Ommen AJ, Smith ED, Hughes PF, Woodward AR, Hanson GJ, McCall WS, Markworth CJ, Hinkley L, Jenks M, Geng L, Lewis M, Otto J, Pronk B, Verleysen K, Hall SE. Huang KH, et al. Among authors: barta te. J Med Chem. 2009 Jul 23;52(14):4288-305. doi: 10.1021/jm900230j. J Med Chem. 2009. PMID: 19552433
22 results