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Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics.
Olmos PR, Hodgson MI, Maiz A, Manrique M, De Valdés MD, Foncea R, Acosta AM, Emmerich MV, Velasco S, Muñiz OP, Oyarzún CA, Claro JC, Bastías MJ, Toro LA. Olmos PR, et al. Among authors: muniz op. Diabetes Res Clin Pract. 2006 Mar;71(3):320-33. doi: 10.1016/j.diabres.2005.07.009. Epub 2005 Oct 17. Diabetes Res Clin Pract. 2006. PMID: 16233932 Clinical Trial.