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A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA. Hummel CW, et al. Among authors: wang y, wang m. J Med Chem. 2005 Nov 3;48(22):6772-5. doi: 10.1021/jm050723z. J Med Chem. 2005. PMID: 16250633
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA. Richardson TI, et al. Among authors: wang m. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. doi: 10.1016/j.bmcl.2007.04.044. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482463
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, Griffin PR. Dai SY, et al. Among authors: wang y, wang m. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7171-6. doi: 10.1073/pnas.0710802105. Epub 2008 May 12. Proc Natl Acad Sci U S A. 2008. PMID: 18474858 Free PMC article.
Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.
Wang M, Winneroski LL, Ardecky RJ, Babine RE, Brooks DA, Etgen GJ, Hutchison DR, Kauffman RF, Kunkel A, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters MK, Rito CJ, Rungta DK, Tripp AE, Wilson SB, Xu Y, Zink RW, McCarthy JR. Wang M, et al. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6113-6. doi: 10.1016/j.bmcl.2004.09.031. Bioorg Med Chem Lett. 2004. PMID: 15546740
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists.
Shi Q, Canada EJ, Xu Y, Warshawsky AM, Etgen GJ, Broderick CL, Clutinger CK, Irwin LA, Laurila ME, Montrose-Rafizadeh C, Oldham BA, Wang M, Winneroski LL, Xie C, York JS, Yumibe NP, Zink RW, Mantlo N. Shi Q, et al. Among authors: wang m. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6744-9. doi: 10.1016/j.bmcl.2007.10.047. Epub 2007 Oct 18. Bioorg Med Chem Lett. 2007. PMID: 18029178
Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
Warshawsky AM, Alt CA, Brozinick JT, Harkness AR, Hawkins ED, Henry JR, Matthews DP, Miller AR, Misener EA, Montrose-Rafizadeh C, Rhodes GA, Shen Q, Vance JA, Udodong UE, Wang M, Zhang TY, Zink RW. Warshawsky AM, et al. Among authors: wang m. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6328-33. doi: 10.1016/j.bmcl.2006.09.011. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17005394
Molecular determinants of LXRalpha agonism.
Wang M, Thomas J, Burris TP, Schkeryantz J, Michael LF. Wang M, et al. J Mol Graph Model. 2003 Nov;22(2):173-81. doi: 10.1016/S1093-3263(03)00159-1. J Mol Graph Model. 2003. PMID: 12932788
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