Zuercher WJ - Search Results

1

Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.

Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Chao EY, et al. Among authors: zuercher wj. Bioorg Med Chem Lett. 2006 Feb 15;16(4):821-4. doi: 10.1016/j.bmcl.2005.11.030. Epub 2005 Nov 22. Bioorg Med Chem Lett. 2006. PMID: 16307879

2

Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.

Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. Zuercher WJ, et al. J Med Chem. 2005 May 5;48(9):3107-9. doi: 10.1021/jm050161j. J Med Chem. 2005. PMID: 15857113

3

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. Wang L, et al. Among authors: zuercher wj. J Biol Chem. 2006 Dec 8;281(49):37773-81. doi: 10.1074/jbc.M608410200. Epub 2006 Sep 21. J Biol Chem. 2006. PMID: 16990259 Free article.

4

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Xue Y, et al. Among authors: zuercher wj. Bioorg Med Chem. 2007 Mar 1;15(5):2156-66. doi: 10.1016/j.bmc.2006.12.026. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17215127 Free PMC article.

5

On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.

Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. Hyatt SM, et al. Among authors: zuercher wj. J Med Chem. 2007 Dec 27;50(26):6722-4. doi: 10.1021/jm7012387. Epub 2007 Dec 4. J Med Chem. 2007. PMID: 18052088 Free PMC article.

6

Recent advances in liver X receptor biology and chemistry.

Goodwin BJ, Zuercher WJ, Collins JL. Goodwin BJ, et al. Among authors: zuercher wj. Curr Top Med Chem. 2008;8(9):781-91. doi: 10.2174/156802608784535075. Curr Top Med Chem. 2008. PMID: 18537688 Review.

7

Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.

Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M, Jaye M, Lazar MA. Phelan CA, et al. Among authors: zuercher wj. Mol Endocrinol. 2008 Oct;22(10):2241-9. doi: 10.1210/me.2008-0041. Epub 2008 Jul 31. Mol Endocrinol. 2008. PMID: 18669643 Free PMC article.

8

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: zuercher wj. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767

9

Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

Zuercher WJ, Buckholz RG, Campobasso N, Collins JL, Galardi CM, Gampe RT, Hyatt SM, Merrihew SL, Moore JT, Oplinger JA, Reid PR, Spearing PK, Stanley TB, Stewart EL, Willson TM. Zuercher WJ, et al. J Med Chem. 2010 Apr 22;53(8):3412-6. doi: 10.1021/jm901797p. J Med Chem. 2010. PMID: 20345102

10

GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ. Grant D, et al. Among authors: zuercher wj. ACS Chem Biol. 2010 Oct 15;5(10):925-32. doi: 10.1021/cb100141y. ACS Chem Biol. 2010. PMID: 20677822

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