La Spada AR - Search Results

1

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

Taylor J, Grote SK, Xia J, Vandelft M, Graczyk J, Ellerby LM, La Spada AR, Truant R. Taylor J, et al. Among authors: la spada ar. J Biol Chem. 2006 Feb 3;281(5):2730-9. doi: 10.1074/jbc.M506751200. Epub 2005 Nov 28. J Biol Chem. 2006. PMID: 16314424 Free article.

2

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

Garden GA, Libby RT, Fu YH, Kinoshita Y, Huang J, Possin DE, Smith AC, Martinez RA, Fine GC, Grote SK, Ware CB, Einum DD, Morrison RS, Ptacek LJ, Sopher BL, La Spada AR. Garden GA, et al. Among authors: la spada ar. J Neurosci. 2002 Jun 15;22(12):4897-905. doi: 10.1523/JNEUROSCI.22-12-04897.2002. J Neurosci. 2002. PMID: 12077187 Free PMC article.

3

Polyglutamines placed into context.

La Spada AR, Taylor JP. La Spada AR, et al. Neuron. 2003 Jun 5;38(5):681-4. doi: 10.1016/s0896-6273(03)00328-3. Neuron. 2003. PMID: 12797953 Free article. Review.

4

Insights into the molecular basis of polyglutamine neurodegeneration from studies of a spinocerebellar ataxia type 7 mouse model.

Grote SK, La Spada AR. Grote SK, et al. Among authors: la spada ar. Cytogenet Genome Res. 2003;100(1-4):164-74. doi: 10.1159/000072851. Cytogenet Genome Res. 2003. PMID: 14526177 Review.

5

Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization.

Chen S, Peng GH, Wang X, Smith AC, Grote SK, Sopher BL, La Spada AR. Chen S, et al. Among authors: la spada ar. Hum Mol Genet. 2004 Jan 1;13(1):53-67. doi: 10.1093/hmg/ddh005. Epub 2003 Nov 12. Hum Mol Genet. 2004. PMID: 14613968

6

Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration.

Sopher BL, Thomas PS Jr, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin LW, Libby RT, Ellerby LM, La Spada AR. Sopher BL, et al. Among authors: la spada ar. Neuron. 2004 Mar 4;41(5):687-99. doi: 10.1016/s0896-6273(04)00082-0. Neuron. 2004. PMID: 15003169 Free article.

7

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Young JE, et al. Among authors: la spada ar. J Biol Chem. 2007 Oct 12;282(41):30150-60. doi: 10.1074/jbc.M705265200. Epub 2007 Jul 23. J Biol Chem. 2007. PMID: 17646170 Free article.

8

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.

Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Young JE, et al. Among authors: la spada ar. J Neurosci. 2009 Feb 18;29(7):1987-97. doi: 10.1523/JNEUROSCI.4072-08.2009. J Neurosci. 2009. PMID: 19228953 Free PMC article.

9

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.

Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. Mookerjee S, et al. Among authors: la spada ar. J Neurosci. 2009 Dec 2;29(48):15134-44. doi: 10.1523/JNEUROSCI.4720-09.2009. J Neurosci. 2009. PMID: 19955365 Free PMC article.

10

Repeat expansion disease: progress and puzzles in disease pathogenesis.

La Spada AR, Taylor JP. La Spada AR, et al. Nat Rev Genet. 2010 Apr;11(4):247-58. doi: 10.1038/nrg2748. Nat Rev Genet. 2010. PMID: 20177426 Free PMC article. Review.

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