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Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Mol Cell Biol. 2005 Dec;25(24):10953-64. doi: 10.1128/MCB.25.24.10953-10964.2005.
Mol Cell Biol. 2005.
PMID: 16314518
Free PMC article.
Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity.
Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI.
Susaki E, et al. Among authors: kaneko oshikawa c.
J Biol Chem. 2010 May 14;285(20):15538-15547. doi: 10.1074/jbc.M110.105841. Epub 2010 Feb 26.
J Biol Chem. 2010.
PMID: 20190229
Free PMC article.
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