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Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.
De Jesus N, Franco D, Paul A, Wimmer E, Cello J. De Jesus N, et al. Among authors: paul a. J Virol. 2005 Nov;79(22):14235-43. doi: 10.1128/JVI.79.22.14235-14243.2005. J Virol. 2005. PMID: 16254358 Free PMC article.
Analyses of variants isolated from sPV(M)-infected CD155 tg mice revealed that the G(102)G(103)-to-G(102)A(103) reversion alone reestablished the neurovirulent phenotype. This suggests that a single mutation is responsible for the observed change of the neurovirulen …
Analyses of variants isolated from sPV(M)-infected CD155 tg mice revealed that the G(102)G(103)-to-G(102)A(103) reversion alone reest …
Functional dissection of a poliovirus cis-acting replication element [PV-cre(2C)]: analysis of single- and dual-cre viral genomes and proteins that bind specifically to PV-cre RNA.
Yin J, Paul AV, Wimmer E, Rieder E. Yin J, et al. J Virol. 2003 May;77(9):5152-66. doi: 10.1128/jvi.77.9.5152-5166.2003. J Virol. 2003. PMID: 12692218 Free PMC article.
The role of the cis replication element (cre) in the 2C(ATPase) coding region of the poliovirus (PV) genome has been studied with a series of mutants derived from either a PV1 full-length genome or a replicon (P/L) containing the firefly luciferase reporter g …
The role of the cis replication element (cre) in the 2C(ATPase) coding region of the poliovirus (PV) genome has been studied with a s …
3,698 results