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Citrullination is an inflammation-dependent process.
Makrygiannakis D, af Klint E, Lundberg IE, Löfberg R, Ulfgren AK, Klareskog L, Catrina AI. Makrygiannakis D, et al. Ann Rheum Dis. 2006 Sep;65(9):1219-22. doi: 10.1136/ard.2005.049403. Epub 2006 Mar 15. Ann Rheum Dis. 2006. PMID: 16540548 Free PMC article.
The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis.
Raptopoulou AP, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, Klareskog L, Catrina AI, Sidiropoulos P, Boumpas DT. Raptopoulou AP, et al. Among authors: makrygiannakis d. Arthritis Rheum. 2010 Jul;62(7):1870-80. doi: 10.1002/art.27500. Arthritis Rheum. 2010. PMID: 20506224 Free article.
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