End D - Search Results

1

Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas.

Widemann BC, Salzer WL, Arceci RJ, Blaney SM, Fox E, End D, Gillespie A, Whitcomb P, Palumbo JS, Pitney A, Jayaprakash N, Zannikos P, Balis FM. Widemann BC, et al. Among authors: end d. J Clin Oncol. 2006 Jan 20;24(3):507-16. doi: 10.1200/JCO.2005.03.8638. J Clin Oncol. 2006. PMID: 16421428 Clinical Trial.

2

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer.

Zujewski J, Horak ID, Bol CJ, Woestenborghs R, Bowden C, End DW, Piotrovsky VK, Chiao J, Belly RT, Todd A, Kopp WC, Kohler DR, Chow C, Noone M, Hakim FT, Larkin G, Gress RE, Nussenblatt RB, Kremer AB, Cowan KH. Zujewski J, et al. Among authors: end dw. J Clin Oncol. 2000 Feb;18(4):927-41. doi: 10.1200/JCO.2000.18.4.927. J Clin Oncol. 2000. PMID: 10673536 Clinical Trial.

3

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial.

Karp JE, Lancet JE, Kaufmann SH, End DW, Wright JJ, Bol K, Horak I, Tidwell ML, Liesveld J, Kottke TJ, Ange D, Buddharaju L, Gojo I, Highsmith WE, Belly RT, Hohl RJ, Rybak ME, Thibault A, Rosenblatt J. Karp JE, et al. Among authors: end dw. Blood. 2001 Jun 1;97(11):3361-9. doi: 10.1182/blood.v97.11.3361. Blood. 2001. PMID: 11369625 Free article. Clinical Trial.

4

Current status of clinical trials of farnesyltransferase inhibitors.

Karp JE, Kaufmann SH, Adjei AA, Lancet JE, Wright JJ, End DW. Karp JE, et al. Among authors: end dw. Curr Opin Oncol. 2001 Nov;13(6):470-6. doi: 10.1097/00001622-200111000-00009. Curr Opin Oncol. 2001. PMID: 11673687 Review.

5

Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.

Lubet RA, Christov K, You M, Yao R, Steele VE, End DW, Juliana MM, Grubbs CJ. Lubet RA, et al. Among authors: end dw. Mol Cancer Ther. 2006 Apr;5(4):1073-8. doi: 10.1158/1535-7163.MCT-05-0398. Mol Cancer Ther. 2006. PMID: 16648579

6

Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.

Gunning WT, Kramer PM, Lubet RA, Steele VE, End DW, Wouters W, Pereira MA. Gunning WT, et al. Clin Cancer Res. 2003 May;9(5):1927-30. Clin Cancer Res. 2003. PMID: 12738751

7

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Kelland LR, et al. Among authors: end d. Clin Cancer Res. 2001 Nov;7(11):3544-50. Clin Cancer Res. 2001. PMID: 11705875

8

The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.

Delmas C, End D, Rochaix P, Favre G, Toulas C, Cohen-Jonathan E. Delmas C, et al. Among authors: end d. Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6062-8. Clin Cancer Res. 2003. PMID: 14676133

9

Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.

Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M. Yao R, et al. Among authors: end dw. Carcinogenesis. 2006 Jul;27(7):1420-31. doi: 10.1093/carcin/bgi341. Epub 2006 Jan 10. Carcinogenesis. 2006. PMID: 16403772

10

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

End DW, Smets G, Todd AV, Applegate TL, Fuery CJ, Angibaud P, Venet M, Sanz G, Poignet H, Skrzat S, Devine A, Wouters W, Bowden C. End DW, et al. Cancer Res. 2001 Jan 1;61(1):131-7. Cancer Res. 2001. PMID: 11196150

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